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GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors

Several neurological and psychiatric disorders have been associated with impairments in GABAergic inhibitory neurons in the brain. Thus, in the current era of accelerated development of molecular medicine and biologically-based drugs, there is a need to identify gene regulatory sequences that can be...

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Autores principales: Duba-Kiss, Robert, Niibori, Yosuke, Hampson, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521139/
https://www.ncbi.nlm.nih.gov/pubmed/34671313
http://dx.doi.org/10.3389/fneur.2021.745159
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author Duba-Kiss, Robert
Niibori, Yosuke
Hampson, David R.
author_facet Duba-Kiss, Robert
Niibori, Yosuke
Hampson, David R.
author_sort Duba-Kiss, Robert
collection PubMed
description Several neurological and psychiatric disorders have been associated with impairments in GABAergic inhibitory neurons in the brain. Thus, in the current era of accelerated development of molecular medicine and biologically-based drugs, there is a need to identify gene regulatory sequences that can be utilized for selectively manipulating the expression of nucleic acids and proteins in GABAergic neurons. This is particularly important for the use of viral vectors in gene therapy. In this Mini Review, we discuss the use of various gene regulatory elements for targeting GABAergic neurons, with an emphasis on adeno-associated viral vectors, the most widely used class of viral vectors for treating brain diseases.
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spelling pubmed-85211392021-10-19 GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors Duba-Kiss, Robert Niibori, Yosuke Hampson, David R. Front Neurol Neurology Several neurological and psychiatric disorders have been associated with impairments in GABAergic inhibitory neurons in the brain. Thus, in the current era of accelerated development of molecular medicine and biologically-based drugs, there is a need to identify gene regulatory sequences that can be utilized for selectively manipulating the expression of nucleic acids and proteins in GABAergic neurons. This is particularly important for the use of viral vectors in gene therapy. In this Mini Review, we discuss the use of various gene regulatory elements for targeting GABAergic neurons, with an emphasis on adeno-associated viral vectors, the most widely used class of viral vectors for treating brain diseases. Frontiers Media S.A. 2021-10-04 /pmc/articles/PMC8521139/ /pubmed/34671313 http://dx.doi.org/10.3389/fneur.2021.745159 Text en Copyright © 2021 Duba-Kiss, Niibori and Hampson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Duba-Kiss, Robert
Niibori, Yosuke
Hampson, David R.
GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors
title GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors
title_full GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors
title_fullStr GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors
title_full_unstemmed GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors
title_short GABAergic Gene Regulatory Elements Used in Adeno-Associated Viral Vectors
title_sort gabaergic gene regulatory elements used in adeno-associated viral vectors
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521139/
https://www.ncbi.nlm.nih.gov/pubmed/34671313
http://dx.doi.org/10.3389/fneur.2021.745159
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