PI3Kγ promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation

BACKGROUND & AIMS: Phosphatidylinositides-3 kinases (PI3Ks) are promising drug targets for cancer therapy, but blockage of PI3K-AKT signalling causes hyperglycaemia, hyperinsulinaemia, and liver damage in patients, and hepatocellular carcinoma (HCC) in mice. There are 4 PI3Ks: PI3Kα, PI3Kβ, PI3K...

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Detalles Bibliográficos
Autores principales: Becattini, Barbara, Breasson, Ludovic, Sardi, Claudia, Zani, Fabio, Solinas, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521290/
https://www.ncbi.nlm.nih.gov/pubmed/34704005
http://dx.doi.org/10.1016/j.jhepr.2021.100359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521290/
https://www.ncbi.nlm.nih.gov/pubmed/34704005
http://dx.doi.org/10.1016/j.jhepr.2021.100359

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