Cargando…

Case Report: A Pancreatic Ductal Adenocarcinoma Patient With Concurrent Targetable Somatic Novel KANK1-ALK, UPP2-NTRK3 Fusion, and Pathogenetic Germline BRCA Mutation

Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates. The current treatment options for PDAC are relatively scarce due to insufficient understanding of molecular characteristics and subtypes of PDAC. Based on next-generation sequencing (NGS), we first...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Fan, Lu, Le, Tan, Yuan, Duan, Qianqian, Lu, Hongwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521337/ https://www.ncbi.nlm.nih.gov/pubmed/34671564 http://dx.doi.org/10.3389/fonc.2021.757965

Ejemplares similares

KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas
por: Catic, Aida, et al.
Publicado: (2020)

Exceptional Clinical Response to Alectinib in Pancreatic Acinar Cell Carcinoma With a Novel ALK-KANK4 Gene Fusion
por: Gaule, Marina, et al.
Publicado: (2022)

Genomic Features of Solid Tumor Patients Harboring ALK/ROS1/NTRK Gene Fusions
por: Dai, Yinghuan, et al.
Publicado: (2022)

Prevalence of conduct disorder in schoolchildren of Kanke
por: Sarkhel, Sujit, et al.
Publicado: (2006)

Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation
por: Mitchell, Gillian, et al.
Publicado: (2005)

Case of multifocal glioblastoma with four fusion transcripts of ALK, FGFR2, NTRK2, and NTRK3 genes stresses the need for tumor tissue multisampling for transcriptomic analysis
por: Samii, Amir, et al.
Publicado: (2021)

LHC-start skjuts upp – igen
Publicado: (2008)

MMR-deficiency and BRCA2/EGFR/NTRK mutations
por: Gokare, Prashanth, et al.
Publicado: (2017)

Emerging oncogenic fusions other than ALK, ROS1, RET, and NTRK in NSCLC and the role of fusions as resistance mechanisms to targeted therapy
por: Suda, Kenichi, et al.
Publicado: (2020)

Novel ALK Fusion, PPFIBP1-ALK, in Pancreatic Ductal Adenocarcinoma Responsive to Alectinib and Lorlatinib
por: Gower, Arjan, et al.
Publicado: (2020)

Ontogenetic and Pathogenetic Views on Somatic Chromosomal Mosaicism
por: Iourov, Ivan Y., et al.
Publicado: (2019)

ALK, ROS1, RET and NTRK1–3 Gene Fusions in Colorectal and Non-Colorectal Microsatellite-Unstable Cancers
por: Mulkidjan, Rimma S., et al.
Publicado: (2023)

Germline and Somatic BRCA1/2 Mutations in 172 Chinese Women With Epithelial Ovarian Cancer
por: You, Yan, et al.
Publicado: (2020)

The Universal Plausibility Metric (UPM) & Principle (UPP)
por: Abel, David L
Publicado: (2009)

NTRK1 Fusion in Glioblastoma Multiforme
por: Kim, Jinkuk, et al.
Publicado: (2014)

Identifying patients with NTRK fusion cancer
por: Solomon, J P, et al.
Publicado: (2019)

NTRK fusion in Japanese colorectal adenocarcinomas
por: Yamashiro, Yuya, et al.
Publicado: (2021)

A review of NTRK fusions in cancer
por: Manea, Cristina Alexandra, et al.
Publicado: (2022)

Germline BRCA2 and somatic P53 alterations in male breast cancer
por: Csokay, B, et al.
Publicado: (2000)

Germline Testing for Patients With BRCA1/2 Mutations on Somatic Tumor Testing
por: Vlessis, Katherine, et al.
Publicado: (2019)

Complete response to alectinib in ALK-fusion metastatic salivary ductal carcinoma
por: Adashek, Jacob J., et al.
Publicado: (2023)

Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of NTRK, ROS1, and ALK fusion-positive solid tumors
por: Liu, Dazhi, et al.
Publicado: (2018)

Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer
por: Chen, Bo, et al.
Publicado: (2020)

Frequency of Germline and Somatic BRCA1 and BRCA2 Mutations in Prostate Cancer: An Updated Systematic Review and Meta-Analysis
por: Valsecchi, Anna Amela, et al.
Publicado: (2023)

Insights into BRCA Cancer Predisposition from Integrated Germline and Somatic Analyses in 7632 Cancers
por: Yost, Shawn, et al.
Publicado: (2019)

Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signatures
por: Bodily, Weston R., et al.
Publicado: (2020)

Cost-Effectiveness Analysis of Germline and Somatic BRCA Testing in Patients With Advanced Ovarian Cancer
por: Jang, Jaehyeok, et al.
Publicado: (2023)

Correction: NTRK1 Fusion in Glioblastoma Multiforme
Publicado: (2014)

NTRK fusions are extremely rare in bone tumours
por: Lam, Suk Wai, et al.
Publicado: (2021)

UPP1 Promotes Lung Adenocarcinoma Progression through Epigenetic Regulation of Glycolysis
por: Wang, Xuan, et al.
Publicado: (2022)

Platinum response characteristics of patients with pancreatic ductal adenocarcinoma and a germline BRCA1, BRCA2 or PALB2 mutation
por: Wattenberg, Max M., et al.
Publicado: (2019)

Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions
por: Brčić, Iva, et al.
Publicado: (2020)

UPPs, direitos e justica : um estudo de caso das favelas do Vidigal e do Cantagalo
por: Oliveira, Fabiana Luci de
Publicado: (2012)

Tumor Testing for Somatic and Germline BRCA1/BRCA2 Variants in Ovarian Cancer Patients in the Context of Strong Founder Effects
por: Peixoto, Ana, et al.
Publicado: (2020)

Concurrent germline BRCA1, BRCA2, and CHEK2 pathogenic variants in hereditary breast cancer: a case series
por: Sukumar, Jasmine, et al.
Publicado: (2021)

BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing
por: Mafficini, Andrea, et al.
Publicado: (2016)

Influence of BRCA1 Germline Mutations in the Somatic Mutational Burden of Triple-Negative Breast Cancer
por: Ferreira, Elisa Napolitano, et al.
Publicado: (2019)

Validation of the short Arabic UPPS-P Impulsive Behavior Scale
por: Bteich, Ghada, et al.
Publicado: (2017)

Factor Analysis of the Brazilian Version of UPPS Impulsive Behavior Scale
por: Sediyama, Cristina Y. N., et al.
Publicado: (2017)

UPP2: fast and accurate alignment of datasets with fragmentary sequences
por: Park, Minhyuk, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dfvito97qnlb88qnpf5bp2a1bm