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Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer

Tumor-infiltrating lymphocytes (TILs) are a significant prognostic factor in triple-negative breast cancer. However, the clinicopathological significance of TILs in estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer remains unclear. The purpose...

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Autores principales: Honda, Chikako, Kurozumi, Sasagu, Katayama, Ayaka, Hanna-Khalil, Bishoy, Masuda, Kei, Nakazawa, Yuko, Ogino, Misato, Obayashi, Sayaka, Yajima, Reina, Makiguchi, Takaya, Oyama, Tetsunari, Horiguchi, Jun, Shirabe, Ken, Fujii, Takaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521382/
https://www.ncbi.nlm.nih.gov/pubmed/34671471
http://dx.doi.org/10.3892/mco.2021.2414
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author Honda, Chikako
Kurozumi, Sasagu
Katayama, Ayaka
Hanna-Khalil, Bishoy
Masuda, Kei
Nakazawa, Yuko
Ogino, Misato
Obayashi, Sayaka
Yajima, Reina
Makiguchi, Takaya
Oyama, Tetsunari
Horiguchi, Jun
Shirabe, Ken
Fujii, Takaaki
author_facet Honda, Chikako
Kurozumi, Sasagu
Katayama, Ayaka
Hanna-Khalil, Bishoy
Masuda, Kei
Nakazawa, Yuko
Ogino, Misato
Obayashi, Sayaka
Yajima, Reina
Makiguchi, Takaya
Oyama, Tetsunari
Horiguchi, Jun
Shirabe, Ken
Fujii, Takaaki
author_sort Honda, Chikako
collection PubMed
description Tumor-infiltrating lymphocytes (TILs) are a significant prognostic factor in triple-negative breast cancer. However, the clinicopathological significance of TILs in estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer remains unclear. The purpose of the present study was to evaluate the role of TILs in the prognosis of ER-positive and HER2-negative breast cancer. A total of 65 consecutive patients with ER-positive and HER2-negative breast cancer were examined. TILs in stromal tissue (str-TILs) were graded using the International TILs Working Group criteria. The association between several clinicopathological factors and TIL grade were investigated, and the prognostic impact of TILs was compared between luminal A-like and luminal B-like breast cancer. A total of 51 patients (78.5%) had low-grade (0-10%), 11 (16.9%) had intermediate (10-40%) and 3 (4.6%) had high-grade (40-90%) str-TIL levels. There was a significant association between high levels of Ki67 expression and a high str-TIL count. Relapse-free survival was significantly worse in patients with luminal B-like cancer compared with that in patients with luminal A-like cancer. Patients with an intermediate or high str-TIL count had a better prognosis compared with those with a low str-TIL count. All patients with luminal B-like cancer and intermediate or high str-TIL levels developed no recurrence during follow-up. In conclusion, there was a significant correlation between high-grade str-TIL levels and high tumor cell proliferation rate, as well as high levels of Ki67 expression.
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spelling pubmed-85213822021-10-19 Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer Honda, Chikako Kurozumi, Sasagu Katayama, Ayaka Hanna-Khalil, Bishoy Masuda, Kei Nakazawa, Yuko Ogino, Misato Obayashi, Sayaka Yajima, Reina Makiguchi, Takaya Oyama, Tetsunari Horiguchi, Jun Shirabe, Ken Fujii, Takaaki Mol Clin Oncol Articles Tumor-infiltrating lymphocytes (TILs) are a significant prognostic factor in triple-negative breast cancer. However, the clinicopathological significance of TILs in estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer remains unclear. The purpose of the present study was to evaluate the role of TILs in the prognosis of ER-positive and HER2-negative breast cancer. A total of 65 consecutive patients with ER-positive and HER2-negative breast cancer were examined. TILs in stromal tissue (str-TILs) were graded using the International TILs Working Group criteria. The association between several clinicopathological factors and TIL grade were investigated, and the prognostic impact of TILs was compared between luminal A-like and luminal B-like breast cancer. A total of 51 patients (78.5%) had low-grade (0-10%), 11 (16.9%) had intermediate (10-40%) and 3 (4.6%) had high-grade (40-90%) str-TIL levels. There was a significant association between high levels of Ki67 expression and a high str-TIL count. Relapse-free survival was significantly worse in patients with luminal B-like cancer compared with that in patients with luminal A-like cancer. Patients with an intermediate or high str-TIL count had a better prognosis compared with those with a low str-TIL count. All patients with luminal B-like cancer and intermediate or high str-TIL levels developed no recurrence during follow-up. In conclusion, there was a significant correlation between high-grade str-TIL levels and high tumor cell proliferation rate, as well as high levels of Ki67 expression. D.A. Spandidos 2021-12 2021-10-08 /pmc/articles/PMC8521382/ /pubmed/34671471 http://dx.doi.org/10.3892/mco.2021.2414 Text en Copyright: © Honda et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Honda, Chikako
Kurozumi, Sasagu
Katayama, Ayaka
Hanna-Khalil, Bishoy
Masuda, Kei
Nakazawa, Yuko
Ogino, Misato
Obayashi, Sayaka
Yajima, Reina
Makiguchi, Takaya
Oyama, Tetsunari
Horiguchi, Jun
Shirabe, Ken
Fujii, Takaaki
Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer
title Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer
title_full Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer
title_fullStr Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer
title_full_unstemmed Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer
title_short Prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer
title_sort prognostic value of tumor-infiltrating lymphocytes in estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521382/
https://www.ncbi.nlm.nih.gov/pubmed/34671471
http://dx.doi.org/10.3892/mco.2021.2414
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