Impact of a vancomycin loading dose on the achievement of target vancomycin exposure in the first 24 h and on the accompanying risk of nephrotoxicity in critically ill patients

BACKGROUND: The advocated pharmacokinetic/pharmacodynamic (PK/PD) target for vancomycin, AUC/MIC ≥ 400 mg·h/L, may not be reached with a conventional fixed starting dose of 1000 mg in critically ill patients, but increasing the dose may cause nephrotoxicity. OBJECTIVES: To evaluate the effect of a w...

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Detalles Bibliográficos
Autores principales: Hodiamont, C J, Juffermans, N P, Berends, S E, van Vessem, D J, Hakkens, N, Mathôt, R A A, de Jong, M D, van Hest, R M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521408/
https://www.ncbi.nlm.nih.gov/pubmed/34337660
http://dx.doi.org/10.1093/jac/dkab278

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