Lessons from vaccine-induced immune thrombotic thrombocytopenia

Adenoviral vector vaccines are effective against SARS-CoV-2 but have been associated with a rare side effect termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we discuss our understanding of how vaccine-induced antibodies to platelet factor 4 (PF4) form immune complexes that ac...

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Detalles Bibliográficos
Autores principales: Kelton, John Greenhow, Arnold, Donald Mitchell, Nazy, Ishac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521503/
https://www.ncbi.nlm.nih.gov/pubmed/34663971
http://dx.doi.org/10.1038/s41577-021-00642-8
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author Kelton, John Greenhow
Arnold, Donald Mitchell
Nazy, Ishac
author_facet Kelton, John Greenhow
Arnold, Donald Mitchell
Nazy, Ishac
author_sort Kelton, John Greenhow
collection PubMed
description Adenoviral vector vaccines are effective against SARS-CoV-2 but have been associated with a rare side effect termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we discuss our understanding of how vaccine-induced antibodies to platelet factor 4 (PF4) form immune complexes that activate platelets and trigger the thrombotic events seen in VITT.
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spelling pubmed-85215032021-10-18 Lessons from vaccine-induced immune thrombotic thrombocytopenia Kelton, John Greenhow Arnold, Donald Mitchell Nazy, Ishac Nat Rev Immunol Comment Adenoviral vector vaccines are effective against SARS-CoV-2 but have been associated with a rare side effect termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we discuss our understanding of how vaccine-induced antibodies to platelet factor 4 (PF4) form immune complexes that activate platelets and trigger the thrombotic events seen in VITT. Nature Publishing Group UK 2021-10-18 2021 /pmc/articles/PMC8521503/ /pubmed/34663971 http://dx.doi.org/10.1038/s41577-021-00642-8 Text en © Springer Nature Limited 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Kelton, John Greenhow
Arnold, Donald Mitchell
Nazy, Ishac
Lessons from vaccine-induced immune thrombotic thrombocytopenia
title Lessons from vaccine-induced immune thrombotic thrombocytopenia
title_full Lessons from vaccine-induced immune thrombotic thrombocytopenia
title_fullStr Lessons from vaccine-induced immune thrombotic thrombocytopenia
title_full_unstemmed Lessons from vaccine-induced immune thrombotic thrombocytopenia
title_short Lessons from vaccine-induced immune thrombotic thrombocytopenia
title_sort lessons from vaccine-induced immune thrombotic thrombocytopenia
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521503/
https://www.ncbi.nlm.nih.gov/pubmed/34663971
http://dx.doi.org/10.1038/s41577-021-00642-8
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