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Identification of potential genes related to breast cancer brain metastasis in breast cancer patients
Brain metastases (BMs) usually develop in breast cancer (BC) patients. Thus, the molecular mechanisms of breast cancer brain metastasis (BCBM) are of great importance in designing therapeutic strategies to treat or prevent BCBM. The present study attempted to identify novel diagnostic and prognostic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521534/ https://www.ncbi.nlm.nih.gov/pubmed/34541602 http://dx.doi.org/10.1042/BSR20211615 |
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author | Zhang, Lijian Wang, Luxuan Yang, Hua Li, Chunhui Fang, Chuan |
author_facet | Zhang, Lijian Wang, Luxuan Yang, Hua Li, Chunhui Fang, Chuan |
author_sort | Zhang, Lijian |
collection | PubMed |
description | Brain metastases (BMs) usually develop in breast cancer (BC) patients. Thus, the molecular mechanisms of breast cancer brain metastasis (BCBM) are of great importance in designing therapeutic strategies to treat or prevent BCBM. The present study attempted to identify novel diagnostic and prognostic biomarkers of BCBM. Two datasets (GSE125989 and GSE100534) were obtained from the Gene Expression Omnibus (GEO) database to find differentially expressed genes (DEGs) in cases of BC with and without brain metastasis (BM). A total of 146 overlapping DEGs, including 103 up-regulated and 43 down-regulated genes, were identified. Functional enrichment analysis showed that these DEGs were mainly enriched for functions including extracellular matrix (ECM) organization and collagen catabolic fibril organization. Using protein–protein interaction (PPI) and principal component analysis (PCA) analysis, we identified ten key genes, including LAMA4, COL1A1, COL5A2, COL3A1, COL4A1, COL5A1, COL5A3, COL6A3, COL6A2, and COL6A1. Additionally, COL5A1, COL4A1, COL1A1, COL6A1, COL6A2, and COL6A3 were significantly associated with the overall survival of BC patients. Furthermore, COL6A3, COL5A1, and COL4A1 were potentially correlated with BCBM in human epidermal growth factor 2 (HER2) expression. Additionally, the miR-29 family might participate in the process of metastasis by modulating the cancer microenvironment. Based on datasets in the GEO database, several DEGs have been identified as playing potentially important roles in BCBM in BC patients. |
format | Online Article Text |
id | pubmed-8521534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85215342021-10-29 Identification of potential genes related to breast cancer brain metastasis in breast cancer patients Zhang, Lijian Wang, Luxuan Yang, Hua Li, Chunhui Fang, Chuan Biosci Rep Neuroscience Brain metastases (BMs) usually develop in breast cancer (BC) patients. Thus, the molecular mechanisms of breast cancer brain metastasis (BCBM) are of great importance in designing therapeutic strategies to treat or prevent BCBM. The present study attempted to identify novel diagnostic and prognostic biomarkers of BCBM. Two datasets (GSE125989 and GSE100534) were obtained from the Gene Expression Omnibus (GEO) database to find differentially expressed genes (DEGs) in cases of BC with and without brain metastasis (BM). A total of 146 overlapping DEGs, including 103 up-regulated and 43 down-regulated genes, were identified. Functional enrichment analysis showed that these DEGs were mainly enriched for functions including extracellular matrix (ECM) organization and collagen catabolic fibril organization. Using protein–protein interaction (PPI) and principal component analysis (PCA) analysis, we identified ten key genes, including LAMA4, COL1A1, COL5A2, COL3A1, COL4A1, COL5A1, COL5A3, COL6A3, COL6A2, and COL6A1. Additionally, COL5A1, COL4A1, COL1A1, COL6A1, COL6A2, and COL6A3 were significantly associated with the overall survival of BC patients. Furthermore, COL6A3, COL5A1, and COL4A1 were potentially correlated with BCBM in human epidermal growth factor 2 (HER2) expression. Additionally, the miR-29 family might participate in the process of metastasis by modulating the cancer microenvironment. Based on datasets in the GEO database, several DEGs have been identified as playing potentially important roles in BCBM in BC patients. Portland Press Ltd. 2021-10-12 /pmc/articles/PMC8521534/ /pubmed/34541602 http://dx.doi.org/10.1042/BSR20211615 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Neuroscience Zhang, Lijian Wang, Luxuan Yang, Hua Li, Chunhui Fang, Chuan Identification of potential genes related to breast cancer brain metastasis in breast cancer patients |
title | Identification of potential genes related to breast cancer brain metastasis in breast cancer patients |
title_full | Identification of potential genes related to breast cancer brain metastasis in breast cancer patients |
title_fullStr | Identification of potential genes related to breast cancer brain metastasis in breast cancer patients |
title_full_unstemmed | Identification of potential genes related to breast cancer brain metastasis in breast cancer patients |
title_short | Identification of potential genes related to breast cancer brain metastasis in breast cancer patients |
title_sort | identification of potential genes related to breast cancer brain metastasis in breast cancer patients |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521534/ https://www.ncbi.nlm.nih.gov/pubmed/34541602 http://dx.doi.org/10.1042/BSR20211615 |
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