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2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors

[Image: see text] Different five-membered nitrogen-containing heteroaromatics in the position of the typical electrophilic group in prolyl oligopeptidase (PREP) inhibitors were investigated and compared to tetrazole. The 2-imidazoles were highly potent inhibitors of the proteolytic activity. The bin...

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Detalles Bibliográficos
Autores principales:	Pätsi, Henri T., Kilpeläinen, Tommi P., Auno, Samuli, Dillemuth, Pyry M. J., Arja, Khaled, Lahtela-Kakkonen, Maija K., Myöhänen, Timo T., Wallén, Erik A. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521653/ https://www.ncbi.nlm.nih.gov/pubmed/34671446 http://dx.doi.org/10.1021/acsmedchemlett.1c00399

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