Human islet T cells are highly reactive to preproinsulin in type 1 diabetes

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are major self-antigens targeted by T cells. We comprehensively examined preproinsulin specificity of CD8 T cells obtained from pa...

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Detalles Bibliográficos
Autores principales: Anderson, Amanda M., Landry, Laurie G., Alkanani, Aimon A., Pyle, Laura, Powers, Alvin C., Atkinson, Mark A., Mathews, Clayton E., Roep, Bart O., Michels, Aaron W., Nakayama, Maki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521679/
https://www.ncbi.nlm.nih.gov/pubmed/34611019
http://dx.doi.org/10.1073/pnas.2107208118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521679/
https://www.ncbi.nlm.nih.gov/pubmed/34611019
http://dx.doi.org/10.1073/pnas.2107208118

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