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Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer
PURPOSE: To explore clinicopathological characteristics and their prognostic value among young patients with cervical cancer (who are aged ≤25 years old). METHODS: The Surveillance, Epidemiology, and End Results Program (SEER) database was used to extract data on cervical cancer patients. They were...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521751/ https://www.ncbi.nlm.nih.gov/pubmed/34648722 http://dx.doi.org/10.1177/10732748211051558 |
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author | Pan, Shuya Jiang, Wenxiao Xie, Shangdan Zhu, Haiyan Zhu, Xueqiong |
author_facet | Pan, Shuya Jiang, Wenxiao Xie, Shangdan Zhu, Haiyan Zhu, Xueqiong |
author_sort | Pan, Shuya |
collection | PubMed |
description | PURPOSE: To explore clinicopathological characteristics and their prognostic value among young patients with cervical cancer (who are aged ≤25 years old). METHODS: The Surveillance, Epidemiology, and End Results Program (SEER) database was used to extract data on cervical cancer patients. They were then stratified by age as young women (≤25 years old) and old women (26–35 years old) and analyzed for clinicopathology characteristics and treatment modalities. Prognosis was analyzed using Kaplan–Meier survival curve, as well as hazard ratios using Cox regression modeling. The nomogram was developed based on Cox hazards regression model. RESULTS: Compared to 26–35 years old women, patients aged ≤25 years tended to be white ethnicity, unmarried, had earlier stage of disease. There was also a better prognosis among younger cohort. Grade, FIGO stage, histologic subtypes, and surgical modalities influenced the survival outcomes of young patients. Among young cohorts, surgery prolonged the survival time of IA-IIA stage patients while surgical and non-surgical management presented no statistically prognostic difference among patients at IIB-IVB stage. Besides, the nomogram which constructed according to Cox hazards regression model which contained independent prognosis factors including FIGO stage, surgery type, and histologic type of tumor can robustly predict survival of young patients. CONCLUSION: Cervical cancer patients ≤25 years old were uncommon and lived longer than the older patients. Among these young patients at IA-IIA stage, surgical treatment could be more effective at preventing death than non-surgery. The nomogram could perfectly predict the prognosis of young adults and adolescents with cervical cancer. |
format | Online Article Text |
id | pubmed-8521751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-85217512021-10-19 Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer Pan, Shuya Jiang, Wenxiao Xie, Shangdan Zhu, Haiyan Zhu, Xueqiong Cancer Control Original Research Article PURPOSE: To explore clinicopathological characteristics and their prognostic value among young patients with cervical cancer (who are aged ≤25 years old). METHODS: The Surveillance, Epidemiology, and End Results Program (SEER) database was used to extract data on cervical cancer patients. They were then stratified by age as young women (≤25 years old) and old women (26–35 years old) and analyzed for clinicopathology characteristics and treatment modalities. Prognosis was analyzed using Kaplan–Meier survival curve, as well as hazard ratios using Cox regression modeling. The nomogram was developed based on Cox hazards regression model. RESULTS: Compared to 26–35 years old women, patients aged ≤25 years tended to be white ethnicity, unmarried, had earlier stage of disease. There was also a better prognosis among younger cohort. Grade, FIGO stage, histologic subtypes, and surgical modalities influenced the survival outcomes of young patients. Among young cohorts, surgery prolonged the survival time of IA-IIA stage patients while surgical and non-surgical management presented no statistically prognostic difference among patients at IIB-IVB stage. Besides, the nomogram which constructed according to Cox hazards regression model which contained independent prognosis factors including FIGO stage, surgery type, and histologic type of tumor can robustly predict survival of young patients. CONCLUSION: Cervical cancer patients ≤25 years old were uncommon and lived longer than the older patients. Among these young patients at IA-IIA stage, surgical treatment could be more effective at preventing death than non-surgery. The nomogram could perfectly predict the prognosis of young adults and adolescents with cervical cancer. SAGE Publications 2021-10-14 /pmc/articles/PMC8521751/ /pubmed/34648722 http://dx.doi.org/10.1177/10732748211051558 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Pan, Shuya Jiang, Wenxiao Xie, Shangdan Zhu, Haiyan Zhu, Xueqiong Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer |
title | Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer |
title_full | Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer |
title_fullStr | Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer |
title_full_unstemmed | Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer |
title_short | Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer |
title_sort | clinicopathological features and survival of adolescent and young adults with cervical cancer |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521751/ https://www.ncbi.nlm.nih.gov/pubmed/34648722 http://dx.doi.org/10.1177/10732748211051558 |
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