XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis

OBJECTIVE: To investigate the potential correlation between the Arg188His (rs3218536) polymorphism of X-ray repair cross-complementing 2 (XRCC2) and colorectal cancer (CRC) risk, as the association remains unclear. METHODS: The CNKI, PubMed, EMBASE and Cochrane library databases were systematically...

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Autores principales: Wang, Zhiyu, Wei, Yaning, An, Lin, Xi, Chenglin, Wang, Kunjie, Hong, Dan, Shi, Yan, Zang, Aiming, Su, Shenyong, Li, Wenwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Meta Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521768/
https://www.ncbi.nlm.nih.gov/pubmed/34648414
http://dx.doi.org/10.1177/03000605211039473
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author Wang, Zhiyu
Wei, Yaning
An, Lin
Xi, Chenglin
Wang, Kunjie
Hong, Dan
Shi, Yan
Zang, Aiming
Su, Shenyong
Li, Wenwen
author_facet Wang, Zhiyu
Wei, Yaning
An, Lin
Xi, Chenglin
Wang, Kunjie
Hong, Dan
Shi, Yan
Zang, Aiming
Su, Shenyong
Li, Wenwen
author_sort Wang, Zhiyu
collection PubMed
description OBJECTIVE: To investigate the potential correlation between the Arg188His (rs3218536) polymorphism of X-ray repair cross-complementing 2 (XRCC2) and colorectal cancer (CRC) risk, as the association remains unclear. METHODS: The CNKI, PubMed, EMBASE and Cochrane library databases were systematically searched for relevant studies published up to July 2021. Data were extracted from included studies, and analysed for pooled or subgroup odds ratios (ORs) with 95% confidence intervals (CIs) using STATA 12.0 software. RESULTS: Seven published studies were included. Pooled analysis revealed that the XRCC2 Arg188His polymorphism was associated with increased CRC risk (His versus Arg: OR 1.14, 95% CI 1.01, 1.29). Trial Sequential Analysis to test the power of the results showed that they were unreliable and the meta-analysis required additional studies. CONCLUSION: The current meta-analysis suggests that the XRCC2 Arg188His polymorphism may be a risk factor for CRC.
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spelling pubmed-85217682021-10-19 XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis Wang, Zhiyu Wei, Yaning An, Lin Xi, Chenglin Wang, Kunjie Hong, Dan Shi, Yan Zang, Aiming Su, Shenyong Li, Wenwen J Int Med Res Meta Analysis OBJECTIVE: To investigate the potential correlation between the Arg188His (rs3218536) polymorphism of X-ray repair cross-complementing 2 (XRCC2) and colorectal cancer (CRC) risk, as the association remains unclear. METHODS: The CNKI, PubMed, EMBASE and Cochrane library databases were systematically searched for relevant studies published up to July 2021. Data were extracted from included studies, and analysed for pooled or subgroup odds ratios (ORs) with 95% confidence intervals (CIs) using STATA 12.0 software. RESULTS: Seven published studies were included. Pooled analysis revealed that the XRCC2 Arg188His polymorphism was associated with increased CRC risk (His versus Arg: OR 1.14, 95% CI 1.01, 1.29). Trial Sequential Analysis to test the power of the results showed that they were unreliable and the meta-analysis required additional studies. CONCLUSION: The current meta-analysis suggests that the XRCC2 Arg188His polymorphism may be a risk factor for CRC. SAGE Publications 2021-10-14 /pmc/articles/PMC8521768/ /pubmed/34648414 http://dx.doi.org/10.1177/03000605211039473 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meta Analysis
Wang, Zhiyu
Wei, Yaning
An, Lin
Xi, Chenglin
Wang, Kunjie
Hong, Dan
Shi, Yan
Zang, Aiming
Su, Shenyong
Li, Wenwen
XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis
title XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis
title_full XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis
title_fullStr XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis
title_full_unstemmed XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis
title_short XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis
title_sort xrcc2 arg188his polymorphism and colorectal cancer risk: a meta-analysis
topic Meta Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521768/
https://www.ncbi.nlm.nih.gov/pubmed/34648414
http://dx.doi.org/10.1177/03000605211039473
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