Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing

BACKGROUND: Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with MLH1 hypermethylation (MLH1(me+)) and wild-type BRAF and RAS. In this study, dMMR CRCs were screened for oncogene fusions using sequential DNA an...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Li, Ruiyu, Li, Junjie, Yi, Yuting, Liu, Xiaoding, Chen, Jingci, Zhang, Hui, Lu, Junliang, Li, Cami, Wu, Huanwen, Liang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522100/
https://www.ncbi.nlm.nih.gov/pubmed/34657620
http://dx.doi.org/10.1186/s12967-021-03108-6

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