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Constitutive TDO2 expression promotes liver cancer progression by an autocrine IL-6 signaling pathway

BACKGROUND: Increased tryptophan (Trp) metabolism by indoleamine 2,3-dioxygenase (IDO)/tryptophan 2,3-dioxygenase (TDO) represents one of the most studied pathways for immunosuppression in tumor tissues. However, the pro-tumor effects induced by Trp metabolism remain controversial. METHODS: The para...

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Detalles Bibliográficos
Autores principales:	Wu, Zhengzhong, Yan, Leye, Lin, Junqing, Ke, Kun, Yang, Weizhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522106/ https://www.ncbi.nlm.nih.gov/pubmed/34657635 http://dx.doi.org/10.1186/s12935-021-02228-9

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