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Recent progress of iPSC technology in cardiac diseases

It has been nearly 15 years since the discovery of human-induced pluripotent stem cells (iPSCs). During this time, differentiation methods to targeted cells have dramatically improved, and many types of cells in the human body can be currently generated at high efficiency. In the cardiovascular fiel...

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Detalles Bibliográficos
Autores principales: Funakoshi, Shunsuke, Yoshida, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522114/
https://www.ncbi.nlm.nih.gov/pubmed/34657219
http://dx.doi.org/10.1007/s00204-021-03172-3
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author Funakoshi, Shunsuke
Yoshida, Yoshinori
author_facet Funakoshi, Shunsuke
Yoshida, Yoshinori
author_sort Funakoshi, Shunsuke
collection PubMed
description It has been nearly 15 years since the discovery of human-induced pluripotent stem cells (iPSCs). During this time, differentiation methods to targeted cells have dramatically improved, and many types of cells in the human body can be currently generated at high efficiency. In the cardiovascular field, the ability to generate human cardiomyocytes in vitro with the same genetic background as patients has provided a great opportunity to investigate human cardiovascular diseases at the cellular level to clarify the molecular mechanisms underlying the diseases and discover potential therapeutics. Additionally, iPSC-derived cardiomyocytes have provided a powerful platform to study drug-induced cardiotoxicity and identify patients at high risk for the cardiotoxicity; thus, accelerating personalized precision medicine. Moreover, iPSC-derived cardiomyocytes can be sources for cardiac cell therapy. Here, we review these achievements and discuss potential improvements for the future application of iPSC technology in cardiovascular diseases.
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spelling pubmed-85221142021-10-18 Recent progress of iPSC technology in cardiac diseases Funakoshi, Shunsuke Yoshida, Yoshinori Arch Toxicol Review Article It has been nearly 15 years since the discovery of human-induced pluripotent stem cells (iPSCs). During this time, differentiation methods to targeted cells have dramatically improved, and many types of cells in the human body can be currently generated at high efficiency. In the cardiovascular field, the ability to generate human cardiomyocytes in vitro with the same genetic background as patients has provided a great opportunity to investigate human cardiovascular diseases at the cellular level to clarify the molecular mechanisms underlying the diseases and discover potential therapeutics. Additionally, iPSC-derived cardiomyocytes have provided a powerful platform to study drug-induced cardiotoxicity and identify patients at high risk for the cardiotoxicity; thus, accelerating personalized precision medicine. Moreover, iPSC-derived cardiomyocytes can be sources for cardiac cell therapy. Here, we review these achievements and discuss potential improvements for the future application of iPSC technology in cardiovascular diseases. Springer Berlin Heidelberg 2021-10-17 2021 /pmc/articles/PMC8522114/ /pubmed/34657219 http://dx.doi.org/10.1007/s00204-021-03172-3 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Funakoshi, Shunsuke
Yoshida, Yoshinori
Recent progress of iPSC technology in cardiac diseases
title Recent progress of iPSC technology in cardiac diseases
title_full Recent progress of iPSC technology in cardiac diseases
title_fullStr Recent progress of iPSC technology in cardiac diseases
title_full_unstemmed Recent progress of iPSC technology in cardiac diseases
title_short Recent progress of iPSC technology in cardiac diseases
title_sort recent progress of ipsc technology in cardiac diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522114/
https://www.ncbi.nlm.nih.gov/pubmed/34657219
http://dx.doi.org/10.1007/s00204-021-03172-3
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