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Frequency of occurrence and antimicrobial susceptibility of bacteria isolated from respiratory samples of patients hospitalized with pneumonia in Western Europe, Eastern Europe and the USA: results from the SENTRY Antimicrobial Surveillance Program (2016–19)
BACKGROUND: The SENTRY Antimicrobial Surveillance Program monitors the frequency of occurrence and antimicrobial susceptibility of organisms from various infection types worldwide. OBJECTIVES: To evaluate the SENTRY programme results for organisms isolated from respiratory samples of patients hospit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522161/ https://www.ncbi.nlm.nih.gov/pubmed/34671728 http://dx.doi.org/10.1093/jacamr/dlab117 |
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author | Sader, Helio S Streit, Jennifer M Carvalhaes, Cecilia G Huband, Michael D Shortridge, Dee Mendes, Rodrigo E Castanheira, Mariana |
author_facet | Sader, Helio S Streit, Jennifer M Carvalhaes, Cecilia G Huband, Michael D Shortridge, Dee Mendes, Rodrigo E Castanheira, Mariana |
author_sort | Sader, Helio S |
collection | PubMed |
description | BACKGROUND: The SENTRY Antimicrobial Surveillance Program monitors the frequency of occurrence and antimicrobial susceptibility of organisms from various infection types worldwide. OBJECTIVES: To evaluate the SENTRY programme results for organisms isolated from respiratory samples of patients hospitalized with probable pneumonia. METHODS: A total of 28 918 bacterial isolates were consecutively collected (one per patient) in 2016–19 from 121 medical centres located in western Europe (W-EU; n = 7966), eastern Europe (E-EU; n = 3182) and the USA (n = 17 770) and then susceptibility tested by reference broth microdilution methods in a central laboratory. RESULTS: Gram-negative bacilli (GNB) represented 76.3%, 88.6% and 69.1% of organisms; non-fermentative (NF) GNB accounted for 26.9%, 51.8% and 34.6% of organisms in W-EU, E-EU and USA, respectively. Pseudomonas aeruginosa susceptibility to piperacillin/tazobactam and meropenem was 75.4% and 76.9% in W-EU, 57.4% and 48.3% in E-EU, and 76.1% and 74.8% in the USA, respectively. Only 10.4% of Acinetobacter baumannii isolates from E-EU were meropenem susceptible compared with 45.8% in W-EU and 58.8% in the USA. Overall MRSA rates were 21.4% in W-EU and 28.7% in E-EU. In the USA, MRSA rates decreased from 44.8% in 2016 to 40.1% in 2019. Carbapenem resistance among Enterobacterales decreased continuously in the USA from 3.0% in 2016 to 1.7% in 2019 (2.4% overall) and was higher in E-EU (16.6%) than W-EU (2.2%). Klebsiella pneumoniae susceptibility to meropenem was 91.3%, 72.5% and 95.3% in W-EU, E-EU and the USA, respectively. CONCLUSIONS: Rank order and antimicrobial susceptibility of bacteria isolated from patients with pneumonia widely varied by geography. MDR NF-GNB represented an important cause of pneumonia. |
format | Online Article Text |
id | pubmed-8522161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-85221612021-10-19 Frequency of occurrence and antimicrobial susceptibility of bacteria isolated from respiratory samples of patients hospitalized with pneumonia in Western Europe, Eastern Europe and the USA: results from the SENTRY Antimicrobial Surveillance Program (2016–19) Sader, Helio S Streit, Jennifer M Carvalhaes, Cecilia G Huband, Michael D Shortridge, Dee Mendes, Rodrigo E Castanheira, Mariana JAC Antimicrob Resist Brief Report BACKGROUND: The SENTRY Antimicrobial Surveillance Program monitors the frequency of occurrence and antimicrobial susceptibility of organisms from various infection types worldwide. OBJECTIVES: To evaluate the SENTRY programme results for organisms isolated from respiratory samples of patients hospitalized with probable pneumonia. METHODS: A total of 28 918 bacterial isolates were consecutively collected (one per patient) in 2016–19 from 121 medical centres located in western Europe (W-EU; n = 7966), eastern Europe (E-EU; n = 3182) and the USA (n = 17 770) and then susceptibility tested by reference broth microdilution methods in a central laboratory. RESULTS: Gram-negative bacilli (GNB) represented 76.3%, 88.6% and 69.1% of organisms; non-fermentative (NF) GNB accounted for 26.9%, 51.8% and 34.6% of organisms in W-EU, E-EU and USA, respectively. Pseudomonas aeruginosa susceptibility to piperacillin/tazobactam and meropenem was 75.4% and 76.9% in W-EU, 57.4% and 48.3% in E-EU, and 76.1% and 74.8% in the USA, respectively. Only 10.4% of Acinetobacter baumannii isolates from E-EU were meropenem susceptible compared with 45.8% in W-EU and 58.8% in the USA. Overall MRSA rates were 21.4% in W-EU and 28.7% in E-EU. In the USA, MRSA rates decreased from 44.8% in 2016 to 40.1% in 2019. Carbapenem resistance among Enterobacterales decreased continuously in the USA from 3.0% in 2016 to 1.7% in 2019 (2.4% overall) and was higher in E-EU (16.6%) than W-EU (2.2%). Klebsiella pneumoniae susceptibility to meropenem was 91.3%, 72.5% and 95.3% in W-EU, E-EU and the USA, respectively. CONCLUSIONS: Rank order and antimicrobial susceptibility of bacteria isolated from patients with pneumonia widely varied by geography. MDR NF-GNB represented an important cause of pneumonia. Oxford University Press 2021-09-02 /pmc/articles/PMC8522161/ /pubmed/34671728 http://dx.doi.org/10.1093/jacamr/dlab117 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Sader, Helio S Streit, Jennifer M Carvalhaes, Cecilia G Huband, Michael D Shortridge, Dee Mendes, Rodrigo E Castanheira, Mariana Frequency of occurrence and antimicrobial susceptibility of bacteria isolated from respiratory samples of patients hospitalized with pneumonia in Western Europe, Eastern Europe and the USA: results from the SENTRY Antimicrobial Surveillance Program (2016–19) |
title | Frequency of occurrence and antimicrobial susceptibility of bacteria
isolated from respiratory samples of patients hospitalized with pneumonia in
Western Europe, Eastern Europe and the USA: results from the SENTRY
Antimicrobial Surveillance Program (2016–19) |
title_full | Frequency of occurrence and antimicrobial susceptibility of bacteria
isolated from respiratory samples of patients hospitalized with pneumonia in
Western Europe, Eastern Europe and the USA: results from the SENTRY
Antimicrobial Surveillance Program (2016–19) |
title_fullStr | Frequency of occurrence and antimicrobial susceptibility of bacteria
isolated from respiratory samples of patients hospitalized with pneumonia in
Western Europe, Eastern Europe and the USA: results from the SENTRY
Antimicrobial Surveillance Program (2016–19) |
title_full_unstemmed | Frequency of occurrence and antimicrobial susceptibility of bacteria
isolated from respiratory samples of patients hospitalized with pneumonia in
Western Europe, Eastern Europe and the USA: results from the SENTRY
Antimicrobial Surveillance Program (2016–19) |
title_short | Frequency of occurrence and antimicrobial susceptibility of bacteria
isolated from respiratory samples of patients hospitalized with pneumonia in
Western Europe, Eastern Europe and the USA: results from the SENTRY
Antimicrobial Surveillance Program (2016–19) |
title_sort | frequency of occurrence and antimicrobial susceptibility of bacteria
isolated from respiratory samples of patients hospitalized with pneumonia in
western europe, eastern europe and the usa: results from the sentry
antimicrobial surveillance program (2016–19) |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522161/ https://www.ncbi.nlm.nih.gov/pubmed/34671728 http://dx.doi.org/10.1093/jacamr/dlab117 |
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