Cargando…

Risk Factors for Premature Aging in Childhood Cancer Survivors

Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless, most data from the international registers of childhood cancer survivors (CCS) stress that this population of patients is at high risk for l...

Descripción completa

Detalles Bibliográficos
Autores principales: Krawczuk-Rybak, Maryna, Latoch, Eryk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522367/
https://www.ncbi.nlm.nih.gov/pubmed/31280245
http://dx.doi.org/10.34763/devperiodmed.20192302.97103
_version_ 1784585076014579712
author Krawczuk-Rybak, Maryna
Latoch, Eryk
author_facet Krawczuk-Rybak, Maryna
Latoch, Eryk
author_sort Krawczuk-Rybak, Maryna
collection PubMed
description Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless, most data from the international registers of childhood cancer survivors (CCS) stress that this population of patients is at high risk for late sequelae and their biologica/ aging starts earlier in life. Anticancer therapy (chemotherapy, radiotherapy, surgery, immunotherapy) affects the intracellular processes leading to the chronic deterioration of organ function and premature senescence. The present review focuses on the late effects of anticancer treatment on various human organs that may lead to premature aging.
format Online
Article
Text
id pubmed-8522367
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Sciendo
record_format MEDLINE/PubMed
spelling pubmed-85223672021-11-19 Risk Factors for Premature Aging in Childhood Cancer Survivors Krawczuk-Rybak, Maryna Latoch, Eryk Dev Period Med Invited Review Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless, most data from the international registers of childhood cancer survivors (CCS) stress that this population of patients is at high risk for late sequelae and their biologica/ aging starts earlier in life. Anticancer therapy (chemotherapy, radiotherapy, surgery, immunotherapy) affects the intracellular processes leading to the chronic deterioration of organ function and premature senescence. The present review focuses on the late effects of anticancer treatment on various human organs that may lead to premature aging. Sciendo 2019-07-08 /pmc/articles/PMC8522367/ /pubmed/31280245 http://dx.doi.org/10.34763/devperiodmed.20192302.97103 Text en © 2019 Maryna Krawczuk-Rybak, Eryk Latoch, published by Sciendo https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Invited Review
Krawczuk-Rybak, Maryna
Latoch, Eryk
Risk Factors for Premature Aging in Childhood Cancer Survivors
title Risk Factors for Premature Aging in Childhood Cancer Survivors
title_full Risk Factors for Premature Aging in Childhood Cancer Survivors
title_fullStr Risk Factors for Premature Aging in Childhood Cancer Survivors
title_full_unstemmed Risk Factors for Premature Aging in Childhood Cancer Survivors
title_short Risk Factors for Premature Aging in Childhood Cancer Survivors
title_sort risk factors for premature aging in childhood cancer survivors
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522367/
https://www.ncbi.nlm.nih.gov/pubmed/31280245
http://dx.doi.org/10.34763/devperiodmed.20192302.97103
work_keys_str_mv AT krawczukrybakmaryna riskfactorsforprematureaginginchildhoodcancersurvivors
AT latocheryk riskfactorsforprematureaginginchildhoodcancersurvivors