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Risk Factors for Premature Aging in Childhood Cancer Survivors
Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless, most data from the international registers of childhood cancer survivors (CCS) stress that this population of patients is at high risk for l...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522367/ https://www.ncbi.nlm.nih.gov/pubmed/31280245 http://dx.doi.org/10.34763/devperiodmed.20192302.97103 |
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author | Krawczuk-Rybak, Maryna Latoch, Eryk |
author_facet | Krawczuk-Rybak, Maryna Latoch, Eryk |
author_sort | Krawczuk-Rybak, Maryna |
collection | PubMed |
description | Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless, most data from the international registers of childhood cancer survivors (CCS) stress that this population of patients is at high risk for late sequelae and their biologica/ aging starts earlier in life. Anticancer therapy (chemotherapy, radiotherapy, surgery, immunotherapy) affects the intracellular processes leading to the chronic deterioration of organ function and premature senescence. The present review focuses on the late effects of anticancer treatment on various human organs that may lead to premature aging. |
format | Online Article Text |
id | pubmed-8522367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-85223672021-11-19 Risk Factors for Premature Aging in Childhood Cancer Survivors Krawczuk-Rybak, Maryna Latoch, Eryk Dev Period Med Invited Review Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless, most data from the international registers of childhood cancer survivors (CCS) stress that this population of patients is at high risk for late sequelae and their biologica/ aging starts earlier in life. Anticancer therapy (chemotherapy, radiotherapy, surgery, immunotherapy) affects the intracellular processes leading to the chronic deterioration of organ function and premature senescence. The present review focuses on the late effects of anticancer treatment on various human organs that may lead to premature aging. Sciendo 2019-07-08 /pmc/articles/PMC8522367/ /pubmed/31280245 http://dx.doi.org/10.34763/devperiodmed.20192302.97103 Text en © 2019 Maryna Krawczuk-Rybak, Eryk Latoch, published by Sciendo https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Invited Review Krawczuk-Rybak, Maryna Latoch, Eryk Risk Factors for Premature Aging in Childhood Cancer Survivors |
title | Risk Factors for Premature Aging in Childhood Cancer Survivors |
title_full | Risk Factors for Premature Aging in Childhood Cancer Survivors |
title_fullStr | Risk Factors for Premature Aging in Childhood Cancer Survivors |
title_full_unstemmed | Risk Factors for Premature Aging in Childhood Cancer Survivors |
title_short | Risk Factors for Premature Aging in Childhood Cancer Survivors |
title_sort | risk factors for premature aging in childhood cancer survivors |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522367/ https://www.ncbi.nlm.nih.gov/pubmed/31280245 http://dx.doi.org/10.34763/devperiodmed.20192302.97103 |
work_keys_str_mv | AT krawczukrybakmaryna riskfactorsforprematureaginginchildhoodcancersurvivors AT latocheryk riskfactorsforprematureaginginchildhoodcancersurvivors |