Cargando…

Recent Progress in Human Placental Transcriptomics

The placenta serves as a metabolic, respiratory, excretory, and endocrine organ that provides appropriate conditions required for adequate feta/ development during pregnancy. The development of particular structures and proper functioning of the placenta are under the influence of sophisticated path...

Descripción completa

Detalles Bibliográficos
Autores principales: Jóźwik, Marcin, Lipka, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522369/
https://www.ncbi.nlm.nih.gov/pubmed/31280246
http://dx.doi.org/10.34763/devperiodmed.20192302.104108
_version_ 1784585076507410432
author Jóźwik, Marcin
Lipka, Aleksandra
author_facet Jóźwik, Marcin
Lipka, Aleksandra
author_sort Jóźwik, Marcin
collection PubMed
description The placenta serves as a metabolic, respiratory, excretory, and endocrine organ that provides appropriate conditions required for adequate feta/ development during pregnancy. The development of particular structures and proper functioning of the placenta are under the influence of sophisticated pathways controlled by the eexpression of substantial genes that are additionally regulated by long non-coding ribonucleic acids (RNAs). Disruptions to adaptive changes in the placenta/ transcriptome as a response to alterations in the feto-matema/ environment may be associated with pregnancy complications and compromised feta/ outcomes. The aim of the current paper was to present recent findings in transcriptomics of the human placenta. Different approaches in bioinformatic analyses of the RNA-sequencing results were presented. Novel knowledge about the genes and mechanisms that are crucial for the proper development of the placenta is essential for the understanding what stands behind both the norma/ and complicated pregnancy.
format Online
Article
Text
id pubmed-8522369
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Sciendo
record_format MEDLINE/PubMed
spelling pubmed-85223692021-11-19 Recent Progress in Human Placental Transcriptomics Jóźwik, Marcin Lipka, Aleksandra Dev Period Med Current Development The placenta serves as a metabolic, respiratory, excretory, and endocrine organ that provides appropriate conditions required for adequate feta/ development during pregnancy. The development of particular structures and proper functioning of the placenta are under the influence of sophisticated pathways controlled by the eexpression of substantial genes that are additionally regulated by long non-coding ribonucleic acids (RNAs). Disruptions to adaptive changes in the placenta/ transcriptome as a response to alterations in the feto-matema/ environment may be associated with pregnancy complications and compromised feta/ outcomes. The aim of the current paper was to present recent findings in transcriptomics of the human placenta. Different approaches in bioinformatic analyses of the RNA-sequencing results were presented. Novel knowledge about the genes and mechanisms that are crucial for the proper development of the placenta is essential for the understanding what stands behind both the norma/ and complicated pregnancy. Sciendo 2019-07-08 /pmc/articles/PMC8522369/ /pubmed/31280246 http://dx.doi.org/10.34763/devperiodmed.20192302.104108 Text en © 2019 Marcin Jóźwik, Aleksandra Lipka, published by Sciendo https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Current Development
Jóźwik, Marcin
Lipka, Aleksandra
Recent Progress in Human Placental Transcriptomics
title Recent Progress in Human Placental Transcriptomics
title_full Recent Progress in Human Placental Transcriptomics
title_fullStr Recent Progress in Human Placental Transcriptomics
title_full_unstemmed Recent Progress in Human Placental Transcriptomics
title_short Recent Progress in Human Placental Transcriptomics
title_sort recent progress in human placental transcriptomics
topic Current Development
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522369/
https://www.ncbi.nlm.nih.gov/pubmed/31280246
http://dx.doi.org/10.34763/devperiodmed.20192302.104108
work_keys_str_mv AT jozwikmarcin recentprogressinhumanplacentaltranscriptomics
AT lipkaaleksandra recentprogressinhumanplacentaltranscriptomics