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Rate of reinfections after SARS-CoV-2 primary infection in the population of an Italian province: a cohort study

BACKGROUND: Current data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections are rare, but no information are available on minors and after 12 months of follow-up. METHODS: This retrospective cohort study included all the population of an Italian Province, diagnose...

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Autores principales: Flacco, M E, Acuti Martellucci, C, Soldato, G, Carota, R, Fazii, P, Caponetti, A, Manzoli, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522392/
https://www.ncbi.nlm.nih.gov/pubmed/34492110
http://dx.doi.org/10.1093/pubmed/fdab346
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author Flacco, M E
Acuti Martellucci, C
Soldato, G
Carota, R
Fazii, P
Caponetti, A
Manzoli, L
author_facet Flacco, M E
Acuti Martellucci, C
Soldato, G
Carota, R
Fazii, P
Caponetti, A
Manzoli, L
author_sort Flacco, M E
collection PubMed
description BACKGROUND: Current data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections are rare, but no information are available on minors and after 12 months of follow-up. METHODS: This retrospective cohort study included all the population of an Italian Province, diagnosed with a SARS-CoV-2 infection from March 2020 to May 2021. The primary outcome was the incidence of a reinfection, defined as a new positive polymerase chain reaction (PCR) test occurring ≥90 days after complete resolution of the first infection, and data were retrieved from the official datasets (coronavirus disease 2019 [COVID-19], demographic, hospital and co-pay exemption) of the Local Health Unit (LHU) of Pescara. RESULTS: After an average of 201 days of follow-up (max. 414), we recorded 24 reinfections ≥90 days after the resolution of the first 7173 infections (0.33%). Four reinfections required hospitalization, one was lethal. Most of the reinfections (n = 13) occurred 6–9 months after the resolution of the first infection; no new infection was detected 12 or more months later and among the 832 minors. CONCLUSIONS: This study confirms previous findings on a low risk of SARS-CoV-2 reinfection. If confirmed, these findings suggest that more targeted restriction policies can be applied to the subjects that recovered after a first infection.
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spelling pubmed-85223922021-10-20 Rate of reinfections after SARS-CoV-2 primary infection in the population of an Italian province: a cohort study Flacco, M E Acuti Martellucci, C Soldato, G Carota, R Fazii, P Caponetti, A Manzoli, L J Public Health (Oxf) Short Report BACKGROUND: Current data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections are rare, but no information are available on minors and after 12 months of follow-up. METHODS: This retrospective cohort study included all the population of an Italian Province, diagnosed with a SARS-CoV-2 infection from March 2020 to May 2021. The primary outcome was the incidence of a reinfection, defined as a new positive polymerase chain reaction (PCR) test occurring ≥90 days after complete resolution of the first infection, and data were retrieved from the official datasets (coronavirus disease 2019 [COVID-19], demographic, hospital and co-pay exemption) of the Local Health Unit (LHU) of Pescara. RESULTS: After an average of 201 days of follow-up (max. 414), we recorded 24 reinfections ≥90 days after the resolution of the first 7173 infections (0.33%). Four reinfections required hospitalization, one was lethal. Most of the reinfections (n = 13) occurred 6–9 months after the resolution of the first infection; no new infection was detected 12 or more months later and among the 832 minors. CONCLUSIONS: This study confirms previous findings on a low risk of SARS-CoV-2 reinfection. If confirmed, these findings suggest that more targeted restriction policies can be applied to the subjects that recovered after a first infection. Oxford University Press 2021-09-08 /pmc/articles/PMC8522392/ /pubmed/34492110 http://dx.doi.org/10.1093/pubmed/fdab346 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Short Report
Flacco, M E
Acuti Martellucci, C
Soldato, G
Carota, R
Fazii, P
Caponetti, A
Manzoli, L
Rate of reinfections after SARS-CoV-2 primary infection in the population of an Italian province: a cohort study
title Rate of reinfections after SARS-CoV-2 primary infection in the population of an Italian province: a cohort study
title_full Rate of reinfections after SARS-CoV-2 primary infection in the population of an Italian province: a cohort study
title_fullStr Rate of reinfections after SARS-CoV-2 primary infection in the population of an Italian province: a cohort study
title_full_unstemmed Rate of reinfections after SARS-CoV-2 primary infection in the population of an Italian province: a cohort study
title_short Rate of reinfections after SARS-CoV-2 primary infection in the population of an Italian province: a cohort study
title_sort rate of reinfections after sars-cov-2 primary infection in the population of an italian province: a cohort study
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522392/
https://www.ncbi.nlm.nih.gov/pubmed/34492110
http://dx.doi.org/10.1093/pubmed/fdab346
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