Cargando…

Subjective cognitive complaints at age 70: associations with amyloid and mental health

OBJECTIVE: To investigate subjective cognitive decline (SCD) in relation to β-amyloid pathology and to test for associations with anxiety, depression, objective cognition and family history of dementia in the Insight 46 study. METHODS: Cognitively unimpaired ~70-year-old participants, all born in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pavisic, Ivanna M., Lu, Kirsty, Keuss, Sarah E., James, Sarah-Naomi, Lane, Christopher A., Parker, Thomas D., Keshavan, Ashvini, Buchanan, Sarah M., Murray-Smith, Heidi, Cash, David M., Coath, William, Wong, Andrew, Fox, Nick C., Crutch, Sebastian J., Richards, Marcus, Schott, Jonathan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Neurodegeneration
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522456/ https://www.ncbi.nlm.nih.gov/pubmed/34035132 http://dx.doi.org/10.1136/jnnp-2020-325620

Ejemplares similares

Pure tone audiometry and cerebral pathology in healthy older adults
por: Parker, Thomas, et al.
Publicado: (2020)

Increased variability in reaction time is associated with amyloid beta pathology at age 70
por: Lu, Kirsty, et al.
Publicado: (2020)

Cognition at age 70: Life course predictors and associations with brain pathologies
por: Lu, Kirsty, et al.
Publicado: (2019)

Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort
por: Buchanan, Sarah M., et al.
Publicado: (2020)

Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest
por: Foiani, Martha S, et al.
Publicado: (2019)

Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort
por: James, Sarah-Naomi, et al.
Publicado: (2023)

Amyloid β influences the relationship between cortical thickness and vascular load
por: Parker, Thomas D., et al.
Publicado: (2020)

An algorithmic approach to structural imaging in dementia
por: Harper, Lorna, et al.
Publicado: (2014)

Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds
por: James, Sarah-Naomi, et al.
Publicado: (2023)

Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
por: Wilson, Katherine M, et al.
Publicado: (2022)

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans
por: Maccecchini, Maria L, et al.
Publicado: (2012)

Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort
por: Keuss, Sarah E., et al.
Publicado: (2022)

Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis
por: Harper, Lorna, et al.
Publicado: (2017)

Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays
por: Keshavan, Ashvini, et al.
Publicado: (2020)

Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays
por: Keshavan, Ashvini, et al.
Publicado: (2021)

Population-based blood screening for preclinical Alzheimer’s disease in a British birth cohort at age 70
por: Keshavan, Ashvini, et al.
Publicado: (2021)

Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function
por: Lehmann, Sylvain, et al.
Publicado: (2023)

Plasma tau is increased in frontotemporal dementia
por: Foiani, Martha S, et al.
Publicado: (2018)

Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study
por: Wagen, Aaron Z, et al.
Publicado: (2022)

Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer’s disease
por: Lu, Kirsty, et al.
Publicado: (2021)

Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington’s disease (Enroll-HD)
por: Harris, Kate L, et al.
Publicado: (2020)

Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study
por: Lane, Christopher A, et al.
Publicado: (2019)

Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records
por: Evans, Stephen JW, et al.
Publicado: (2013)

Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias
por: Mehta, Puja R, et al.
Publicado: (2019)

A clinical tool for predicting survival in ALS
por: Knibb, Jonathan A, et al.
Publicado: (2016)

Relative preservation of triceps over biceps strength in upper limb-onset ALS: the ‘split elbow’
por: Khalaf, Roaya, et al.
Publicado: (2019)

Hippocampal subfield volumes and pre-clinical Alzheimer’s disease in 408 cognitively normal adults born in 1946
por: Parker, Thomas D., et al.
Publicado: (2019)

Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort
por: Lane, Christopher A., et al.
Publicado: (2019)

CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer’s disease
por: Teuber-Hanselmann, Sarah, et al.
Publicado: (2020)

Development of novel clinical examination scales for the measurement of disease severity in Creutzfeldt-Jakob disease
por: Nihat, Akin, et al.
Publicado: (2022)

Neuronal pentraxin 2: a synapse-derived CSF biomarker in genetic frontotemporal dementia
por: van der Ende, Emma L, et al.
Publicado: (2020)

Platelet abnormalities in Huntington’s disease
por: Denis, Hélèna L, et al.
Publicado: (2019)

A population‐based study of head injury, cognitive function and pathological markers
por: James, Sarah‐Naomi, et al.
Publicado: (2021)

Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46
por: James, Sarah-Naomi, et al.
Publicado: (2018)

Investigating the relationship between BMI across adulthood and late life brain pathologies
por: Lane, Christopher A., et al.
Publicado: (2021)

Neuronal network disintegration: common pathways linking neurodegenerative diseases
por: Ahmed, Rebekah M, et al.
Publicado: (2016)

Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management
por: O'Brien, John, et al.
Publicado: (2020)

Hypermetabolism in ALS is associated with greater functional decline and shorter survival
por: Steyn, Frederik J, et al.
Publicado: (2018)

Cognition and behaviour in frontotemporal dementia with and without amyotrophic lateral sclerosis
por: Saxon, Jennifer A, et al.
Publicado: (2020)

Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS
por: Gregory, Jenna M, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_h4799c4l8d4kbm7r581k7fkn51