Cargando…

Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies

OBJECTIVES: The magnitude of the genetic contribution to idiopathic inflammatory myopathies (IIMs) is unknown. In this project, we aimed to investigate the familial aggregation and heritability of IIM. METHODS: This is a family-based study using nationwide healthcare register data in Sweden. We matc...

Descripción completa

Detalles Bibliográficos
Autores principales: Che, Weng Ian, Westerlind, Helga, Lundberg, Ingrid E, Hellgren, Karin, Kuja-Halkola, Ralf, Holmqvist, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522465/
https://www.ncbi.nlm.nih.gov/pubmed/34130985
http://dx.doi.org/10.1136/annrheumdis-2021-219914
_version_ 1784585093346492416
author Che, Weng Ian
Westerlind, Helga
Lundberg, Ingrid E
Hellgren, Karin
Kuja-Halkola, Ralf
Holmqvist, Marie
author_facet Che, Weng Ian
Westerlind, Helga
Lundberg, Ingrid E
Hellgren, Karin
Kuja-Halkola, Ralf
Holmqvist, Marie
author_sort Che, Weng Ian
collection PubMed
description OBJECTIVES: The magnitude of the genetic contribution to idiopathic inflammatory myopathies (IIMs) is unknown. In this project, we aimed to investigate the familial aggregation and heritability of IIM. METHODS: This is a family-based study using nationwide healthcare register data in Sweden. We matched each patient with IIM to individuals without IIM, identified their first-degree relatives and determined the IIM status among all first-degree relatives. We estimated the adjusted ORs (aORs) of familial aggregation of IIM using conditional logistic regression. In addition, we used tetrachoric correlation to estimate the heritability of IIM. RESULTS: We included 7615 first-degree relatives of 1620 patients with IIM diagnosed between 1997 and 2016 and 37 309 first-degree relatives of 7797 individuals without IIM. Compared with individuals without IIM, patients with IIM were more likely to have ≥1 first-degree relative affected by IIM (aOR=4.32, 95% CI 2.00 to 9.34). Furthermore, the aOR of familial aggregation of IIM in full siblings was 2.53 (95% CI 1.62 to 3.96). The heritability of IIM was 22% (95% CI 12% to 31%) among any first-degree relatives and 24% (95% CI 12% to 37%) among full siblings. CONCLUSIONS: IIM has a familial component with a risk of aggregation among first-degree relatives and a heritability of about 20%. This information is of importance for future aetiological studies and in clinical counselling.
format Online
Article
Text
id pubmed-8522465
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-85224652021-10-29 Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies Che, Weng Ian Westerlind, Helga Lundberg, Ingrid E Hellgren, Karin Kuja-Halkola, Ralf Holmqvist, Marie Ann Rheum Dis Myositis OBJECTIVES: The magnitude of the genetic contribution to idiopathic inflammatory myopathies (IIMs) is unknown. In this project, we aimed to investigate the familial aggregation and heritability of IIM. METHODS: This is a family-based study using nationwide healthcare register data in Sweden. We matched each patient with IIM to individuals without IIM, identified their first-degree relatives and determined the IIM status among all first-degree relatives. We estimated the adjusted ORs (aORs) of familial aggregation of IIM using conditional logistic regression. In addition, we used tetrachoric correlation to estimate the heritability of IIM. RESULTS: We included 7615 first-degree relatives of 1620 patients with IIM diagnosed between 1997 and 2016 and 37 309 first-degree relatives of 7797 individuals without IIM. Compared with individuals without IIM, patients with IIM were more likely to have ≥1 first-degree relative affected by IIM (aOR=4.32, 95% CI 2.00 to 9.34). Furthermore, the aOR of familial aggregation of IIM in full siblings was 2.53 (95% CI 1.62 to 3.96). The heritability of IIM was 22% (95% CI 12% to 31%) among any first-degree relatives and 24% (95% CI 12% to 37%) among full siblings. CONCLUSIONS: IIM has a familial component with a risk of aggregation among first-degree relatives and a heritability of about 20%. This information is of importance for future aetiological studies and in clinical counselling. BMJ Publishing Group 2021-11 2021-06-15 /pmc/articles/PMC8522465/ /pubmed/34130985 http://dx.doi.org/10.1136/annrheumdis-2021-219914 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Myositis
Che, Weng Ian
Westerlind, Helga
Lundberg, Ingrid E
Hellgren, Karin
Kuja-Halkola, Ralf
Holmqvist, Marie
Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
title Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
title_full Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
title_fullStr Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
title_full_unstemmed Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
title_short Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
title_sort familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
topic Myositis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522465/
https://www.ncbi.nlm.nih.gov/pubmed/34130985
http://dx.doi.org/10.1136/annrheumdis-2021-219914
work_keys_str_mv AT chewengian familialaggregationandheritabilityanationwidefamilybasedstudyofidiopathicinflammatorymyopathies
AT westerlindhelga familialaggregationandheritabilityanationwidefamilybasedstudyofidiopathicinflammatorymyopathies
AT lundbergingride familialaggregationandheritabilityanationwidefamilybasedstudyofidiopathicinflammatorymyopathies
AT hellgrenkarin familialaggregationandheritabilityanationwidefamilybasedstudyofidiopathicinflammatorymyopathies
AT kujahalkolaralf familialaggregationandheritabilityanationwidefamilybasedstudyofidiopathicinflammatorymyopathies
AT holmqvistmarie familialaggregationandheritabilityanationwidefamilybasedstudyofidiopathicinflammatorymyopathies