A Case with (68)Ga-FAPI Positive and (18)F-FDG Negative Breast Cancer

A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwent (18)flourine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for staging. The tumor was located in the superior external quadrant of the right breast, and did not exhib...

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Autores principales: Kömek, Halil, Gündoğan, Cihan, Etem, Hülya, Can, Canan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2021
Materias:
Interesting Image
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522513/
https://www.ncbi.nlm.nih.gov/pubmed/34661066
http://dx.doi.org/10.4274/mirt.galenos.2021.69926
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author Kömek, Halil
Gündoğan, Cihan
Etem, Hülya
Can, Canan
author_facet Kömek, Halil
Gündoğan, Cihan
Etem, Hülya
Can, Canan
author_sort Kömek, Halil
collection PubMed
description A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwent (18)flourine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for staging. The tumor was located in the superior external quadrant of the right breast, and did not exhibit pathological uptake in (18)F-FDG PET/CT. Later, gallium-(68) ((68)Ga) fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT imaging was performed and the primary tumor showed intense radiotracer accumulation. This presumes that (68)Ga-FAPI PET/CT imaging is superior to (18)F-FDG imaging in detecting the primary tumor in breast cancer, thereby suggesting the replacement of FAPI by (18)F-FDG in breast-cancer staging in the future.
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spelling pubmed-85225132021-10-26 A Case with (68)Ga-FAPI Positive and (18)F-FDG Negative Breast Cancer Kömek, Halil Gündoğan, Cihan Etem, Hülya Can, Canan Mol Imaging Radionucl Ther Interesting Image A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwent (18)flourine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for staging. The tumor was located in the superior external quadrant of the right breast, and did not exhibit pathological uptake in (18)F-FDG PET/CT. Later, gallium-(68) ((68)Ga) fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT imaging was performed and the primary tumor showed intense radiotracer accumulation. This presumes that (68)Ga-FAPI PET/CT imaging is superior to (18)F-FDG imaging in detecting the primary tumor in breast cancer, thereby suggesting the replacement of FAPI by (18)F-FDG in breast-cancer staging in the future. Galenos Publishing 2021-10 2021-10-15 /pmc/articles/PMC8522513/ /pubmed/34661066 http://dx.doi.org/10.4274/mirt.galenos.2021.69926 Text en ©Copyright 2021 by Turkish Society of Nuclear Medicine | Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Interesting Image
Kömek, Halil
Gündoğan, Cihan
Etem, Hülya
Can, Canan
A Case with (68)Ga-FAPI Positive and (18)F-FDG Negative Breast Cancer
title A Case with (68)Ga-FAPI Positive and (18)F-FDG Negative Breast Cancer
title_full A Case with (68)Ga-FAPI Positive and (18)F-FDG Negative Breast Cancer
title_fullStr A Case with (68)Ga-FAPI Positive and (18)F-FDG Negative Breast Cancer
title_full_unstemmed A Case with (68)Ga-FAPI Positive and (18)F-FDG Negative Breast Cancer
title_short A Case with (68)Ga-FAPI Positive and (18)F-FDG Negative Breast Cancer
title_sort case with (68)ga-fapi positive and (18)f-fdg negative breast cancer
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522513/
https://www.ncbi.nlm.nih.gov/pubmed/34661066
http://dx.doi.org/10.4274/mirt.galenos.2021.69926
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