Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse

Motile cilia and flagellar defects can result in primary ciliary dyskinesia, which is a multisystemic genetic disorder that affects roughly 1:10 000 individuals. The nexin-dynein regulatory complex (N-DRC) links neighboring doublet microtubules within flagella, serving as a central regulatory hub fo...

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Detalles Bibliográficos
Autores principales: Zhang, Jintao, He, Xiaojin, Wu, Huan, Zhang, Xin, Yang, Shenmin, Liu, Chunyu, Liu, Siyu, Hua, Rong, Zhou, Shushu, Zhao, Shuqin, Hu, Fan, Zhang, Junqiang, Liu, Wangjie, Cheng, Huiru, Gao, Yang, Zhang, Feng, Cao, Yunxia, Liu, Mingxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522639/
https://www.ncbi.nlm.nih.gov/pubmed/34169321
http://dx.doi.org/10.1093/hmg/ddab171

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