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Possibilities for personalised medicine in rheumatoid arthritis: hype or hope

Knowledge of pathophysiology of rheumatoid arthritis (RA) has improved over the past decades, which resulted in new treatment options and strategies that led to better clinical outcomes. At the same time, we have come to understand that RA is a heterogeneous disease on a clinical as well as a pathop...

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Detalles Bibliográficos
Autores principales: Heutz, Judith, de Jong, Pascal Hendrik Pieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522666/
https://www.ncbi.nlm.nih.gov/pubmed/34649986
http://dx.doi.org/10.1136/rmdopen-2021-001653
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author Heutz, Judith
de Jong, Pascal Hendrik Pieter
author_facet Heutz, Judith
de Jong, Pascal Hendrik Pieter
author_sort Heutz, Judith
collection PubMed
description Knowledge of pathophysiology of rheumatoid arthritis (RA) has improved over the past decades, which resulted in new treatment options and strategies that led to better clinical outcomes. At the same time, we have come to understand that RA is a heterogeneous disease on a clinical as well as a pathophysiological level. Despite this heterogeneity, current management recommendations still adopt a ‘one-size-fits-all’ treatment approach, where ideally individualised treatment, or personalised medicine, is preferred. The first step towards personalised medicine in RA would be to designate different treatment strategies to distinct clinical or molecular phenotypes of patients. This viewpoint discusses current evidence and elaborates on future possibilities for personalised medicine in RA.
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spelling pubmed-85226662021-11-02 Possibilities for personalised medicine in rheumatoid arthritis: hype or hope Heutz, Judith de Jong, Pascal Hendrik Pieter RMD Open Rheumatoid Arthritis Knowledge of pathophysiology of rheumatoid arthritis (RA) has improved over the past decades, which resulted in new treatment options and strategies that led to better clinical outcomes. At the same time, we have come to understand that RA is a heterogeneous disease on a clinical as well as a pathophysiological level. Despite this heterogeneity, current management recommendations still adopt a ‘one-size-fits-all’ treatment approach, where ideally individualised treatment, or personalised medicine, is preferred. The first step towards personalised medicine in RA would be to designate different treatment strategies to distinct clinical or molecular phenotypes of patients. This viewpoint discusses current evidence and elaborates on future possibilities for personalised medicine in RA. BMJ Publishing Group 2021-10-14 /pmc/articles/PMC8522666/ /pubmed/34649986 http://dx.doi.org/10.1136/rmdopen-2021-001653 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Rheumatoid Arthritis
Heutz, Judith
de Jong, Pascal Hendrik Pieter
Possibilities for personalised medicine in rheumatoid arthritis: hype or hope
title Possibilities for personalised medicine in rheumatoid arthritis: hype or hope
title_full Possibilities for personalised medicine in rheumatoid arthritis: hype or hope
title_fullStr Possibilities for personalised medicine in rheumatoid arthritis: hype or hope
title_full_unstemmed Possibilities for personalised medicine in rheumatoid arthritis: hype or hope
title_short Possibilities for personalised medicine in rheumatoid arthritis: hype or hope
title_sort possibilities for personalised medicine in rheumatoid arthritis: hype or hope
topic Rheumatoid Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522666/
https://www.ncbi.nlm.nih.gov/pubmed/34649986
http://dx.doi.org/10.1136/rmdopen-2021-001653
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