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Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses

Every year, millions of people worldwide are infected with dengue virus (DENV), with a significant number developing severe life-threatening disease. There are currently no broadly indicated vaccines or therapeutics available for treatment of DENV infection. Here, we show that AT-281, the free base...

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Detalles Bibliográficos
Autores principales:	Good, Steven S., Shannon, Ashleigh, Lin, Kai, Moussa, Adel, Julander, Justin G., La Colla, Paolo, Collu, Gabriella, Canard, Bruno, Sommadossi, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522752/ https://www.ncbi.nlm.nih.gov/pubmed/34424050 http://dx.doi.org/10.1128/AAC.00988-21

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