Relationship between Plasma and Intracellular Concentrations of Bedaquiline and Its M2 Metabolite in South African Patients with Rifampin-Resistant Tuberculosis

Bedaquiline is recommended for the treatment of all patients with rifampin-resistant tuberculosis (RR-TB). Bedaquiline accumulates within cells, but its intracellular pharmacokinetics have not been characterized, which may have implications for dose optimization. We developed a novel assay using hig...

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Detalles Bibliográficos
Autores principales: Ngwalero, Precious, Brust, James C. M., van Beek, Stijn W., Wasserman, Sean, Maartens, Gary, Meintjes, Graeme, Joubert, Anton, Norman, Jennifer, Castel, Sandra, Gandhi, Neel R., Denti, Paolo, McIlleron, Helen, Svensson, Elin M., Wiesner, Lubbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522761/
https://www.ncbi.nlm.nih.gov/pubmed/34370588
http://dx.doi.org/10.1128/AAC.02399-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522761/
https://www.ncbi.nlm.nih.gov/pubmed/34370588
http://dx.doi.org/10.1128/AAC.02399-20

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