A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro

An evaluation of the anti-Mycobacterium abscessus activity expressed by a novel oxazolidinone, contezolid (MRX-I), toward 12 reference strains and 194 clinical isolates was conducted. Contezolid was active against M. abscessus in vitro, with effects comparable to the anti-M. abscessus effects of lin...

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Autores principales: Guo, Qi, Xu, Liyun, Tan, Fusheng, Zhang, Yongjie, Fan, Junsheng, Wang, Xinghai, Zhang, Zhemin, Li, Bing, Chu, Haiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522767/
https://www.ncbi.nlm.nih.gov/pubmed/34460305
http://dx.doi.org/10.1128/AAC.00889-21
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author Guo, Qi
Xu, Liyun
Tan, Fusheng
Zhang, Yongjie
Fan, Junsheng
Wang, Xinghai
Zhang, Zhemin
Li, Bing
Chu, Haiqing
author_facet Guo, Qi
Xu, Liyun
Tan, Fusheng
Zhang, Yongjie
Fan, Junsheng
Wang, Xinghai
Zhang, Zhemin
Li, Bing
Chu, Haiqing
author_sort Guo, Qi
collection PubMed
description An evaluation of the anti-Mycobacterium abscessus activity expressed by a novel oxazolidinone, contezolid (MRX-I), toward 12 reference strains and 194 clinical isolates was conducted. Contezolid was active against M. abscessus in vitro, with effects comparable to the anti-M. abscessus effects of linezolid both extracellularly and intracellularly. Contezolid did not antagonize the most frequently used anti-M. abscessus drugs, and preexposure to contezolid did not induce drug resistance. These results provide a novel approach to treating M. abscessus infections.
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spelling pubmed-85227672021-10-20 A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro Guo, Qi Xu, Liyun Tan, Fusheng Zhang, Yongjie Fan, Junsheng Wang, Xinghai Zhang, Zhemin Li, Bing Chu, Haiqing Antimicrob Agents Chemother Susceptibility An evaluation of the anti-Mycobacterium abscessus activity expressed by a novel oxazolidinone, contezolid (MRX-I), toward 12 reference strains and 194 clinical isolates was conducted. Contezolid was active against M. abscessus in vitro, with effects comparable to the anti-M. abscessus effects of linezolid both extracellularly and intracellularly. Contezolid did not antagonize the most frequently used anti-M. abscessus drugs, and preexposure to contezolid did not induce drug resistance. These results provide a novel approach to treating M. abscessus infections. American Society for Microbiology 2021-10-18 /pmc/articles/PMC8522767/ /pubmed/34460305 http://dx.doi.org/10.1128/AAC.00889-21 Text en Copyright © 2021 Guo et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Susceptibility
Guo, Qi
Xu, Liyun
Tan, Fusheng
Zhang, Yongjie
Fan, Junsheng
Wang, Xinghai
Zhang, Zhemin
Li, Bing
Chu, Haiqing
A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
title A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
title_full A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
title_fullStr A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
title_full_unstemmed A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
title_short A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
title_sort novel oxazolidinone, contezolid (mrx-i), expresses anti-mycobacterium abscessus activity in vitro
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522767/
https://www.ncbi.nlm.nih.gov/pubmed/34460305
http://dx.doi.org/10.1128/AAC.00889-21
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