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24-Norursodeoxycholic acid reshapes immunometabolism in CD8(+) T cells and alleviates hepatic inflammation

BACKGROUND & AIMS: 24-Norursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid used to treat immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC), where dysregulated T cells including CD8(+) T cells contribute to hepatobiliary immunopathology. We hyp...

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Detalles Bibliográficos
Autores principales:	Zhu, Ci, Boucheron, Nicole, Müller, André C., Májek, Peter, Claudel, Thierry, Halilbasic, Emina, Baazim, Hatoon, Lercher, Alexander, Viczenczova, Csilla, Hainberger, Daniela, Preglej, Teresa, Sandner, Lisa, Alteneder, Marlis, Gülich, Alexandra F., Khan, Matarr, Hamminger, Patricia, Remetic, Jelena, Ohradanova-Repic, Anna, Schatzlmaier, Philipp, Donner, Clemens, Fuchs, Claudia D., Stojakovic, Tatjana, Scharnagl, Hubert, Sakaguchi, Shinya, Weichhart, Thomas, Bergthaler, Andreas, Stockinger, Hannes, Ellmeier, Wilfried, Trauner, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522806/ https://www.ncbi.nlm.nih.gov/pubmed/34242699 http://dx.doi.org/10.1016/j.jhep.2021.06.036

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