Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?

Secretin is the first hormone that has been discovered, inaugurating the era and the field of endocrinology. Despite the initial focus, the interest in its actions faded away over the decades. However, there is mounting evidence regarding the pleiotropic beneficial effects of secretin on whole-body...

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Autores principales: Laurila, Sanna, Rebelos, Eleni, Honka, Miikka-Juhani, Nuutila, Pirjo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522834/
https://www.ncbi.nlm.nih.gov/pubmed/34671320
http://dx.doi.org/10.3389/fendo.2021.737686
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author Laurila, Sanna
Rebelos, Eleni
Honka, Miikka-Juhani
Nuutila, Pirjo
author_facet Laurila, Sanna
Rebelos, Eleni
Honka, Miikka-Juhani
Nuutila, Pirjo
author_sort Laurila, Sanna
collection PubMed
description Secretin is the first hormone that has been discovered, inaugurating the era and the field of endocrinology. Despite the initial focus, the interest in its actions faded away over the decades. However, there is mounting evidence regarding the pleiotropic beneficial effects of secretin on whole-body homeostasis. In this review, we discuss the evidence from preclinical and clinical studies based on which secretin may have a role in the treatment of obesity.
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spelling pubmed-85228342021-10-19 Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity? Laurila, Sanna Rebelos, Eleni Honka, Miikka-Juhani Nuutila, Pirjo Front Endocrinol (Lausanne) Endocrinology Secretin is the first hormone that has been discovered, inaugurating the era and the field of endocrinology. Despite the initial focus, the interest in its actions faded away over the decades. However, there is mounting evidence regarding the pleiotropic beneficial effects of secretin on whole-body homeostasis. In this review, we discuss the evidence from preclinical and clinical studies based on which secretin may have a role in the treatment of obesity. Frontiers Media S.A. 2021-10-04 /pmc/articles/PMC8522834/ /pubmed/34671320 http://dx.doi.org/10.3389/fendo.2021.737686 Text en Copyright © 2021 Laurila, Rebelos, Honka and Nuutila https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Laurila, Sanna
Rebelos, Eleni
Honka, Miikka-Juhani
Nuutila, Pirjo
Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
title Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
title_full Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
title_fullStr Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
title_full_unstemmed Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
title_short Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
title_sort pleiotropic effects of secretin: a potential drug candidate in the treatment of obesity?
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522834/
https://www.ncbi.nlm.nih.gov/pubmed/34671320
http://dx.doi.org/10.3389/fendo.2021.737686
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AT honkamiikkajuhani pleiotropiceffectsofsecretinapotentialdrugcandidateinthetreatmentofobesity
AT nuutilapirjo pleiotropiceffectsofsecretinapotentialdrugcandidateinthetreatmentofobesity

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