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Association of four genetic variants with colorectal cancer in Kazakhstan population
The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522836/ https://www.ncbi.nlm.nih.gov/pubmed/34676053 http://dx.doi.org/10.18632/oncotarget.28070 |
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author | Kolesnikova, Yevgeniya Babenko, Dmitriy Kadyrova, Irina Kolesnichenko, Svetlana Akhmaltdinova, Lyudmila Korshukov, Ilya Kabildina, Naylya Sirota, Valentina Zhumaliyeva, Vera Taizhanova, Dana Vazenmiller, Dmitriy Turmukhambetova, Anar |
author_facet | Kolesnikova, Yevgeniya Babenko, Dmitriy Kadyrova, Irina Kolesnichenko, Svetlana Akhmaltdinova, Lyudmila Korshukov, Ilya Kabildina, Naylya Sirota, Valentina Zhumaliyeva, Vera Taizhanova, Dana Vazenmiller, Dmitriy Turmukhambetova, Anar |
author_sort | Kolesnikova, Yevgeniya |
collection | PubMed |
description | The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudio 12K Flex PCR. For four significant SNPs inheritance model analysis was performed. Increasing risk of CRC was noted for rs10795668 in log-additive model (OR = 1.45, 95% CI: 1.05–1.99, p = 0.023); for rs1035209 in log-additive model (OR = 1.79, 95% CI: 1.18–2.72, p = 0.003); for rs11190164 in log-additive model (OR = 1.67, 95% CI: 1.17–2.38, p = 0.004). Decreasing risk of CRC was noted for rs10506868 in log-additive model (OR = 0.56, 95% CI: 0.37–0.85, p = 0.006). We detected SNPs that are associated with CRC risk in the Kazakhstan population. |
format | Online Article Text |
id | pubmed-8522836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-85228362021-10-20 Association of four genetic variants with colorectal cancer in Kazakhstan population Kolesnikova, Yevgeniya Babenko, Dmitriy Kadyrova, Irina Kolesnichenko, Svetlana Akhmaltdinova, Lyudmila Korshukov, Ilya Kabildina, Naylya Sirota, Valentina Zhumaliyeva, Vera Taizhanova, Dana Vazenmiller, Dmitriy Turmukhambetova, Anar Oncotarget Research Paper The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudio 12K Flex PCR. For four significant SNPs inheritance model analysis was performed. Increasing risk of CRC was noted for rs10795668 in log-additive model (OR = 1.45, 95% CI: 1.05–1.99, p = 0.023); for rs1035209 in log-additive model (OR = 1.79, 95% CI: 1.18–2.72, p = 0.003); for rs11190164 in log-additive model (OR = 1.67, 95% CI: 1.17–2.38, p = 0.004). Decreasing risk of CRC was noted for rs10506868 in log-additive model (OR = 0.56, 95% CI: 0.37–0.85, p = 0.006). We detected SNPs that are associated with CRC risk in the Kazakhstan population. Impact Journals LLC 2021-10-12 /pmc/articles/PMC8522836/ /pubmed/34676053 http://dx.doi.org/10.18632/oncotarget.28070 Text en Copyright: © 2021 Kolesnikova et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Kolesnikova, Yevgeniya Babenko, Dmitriy Kadyrova, Irina Kolesnichenko, Svetlana Akhmaltdinova, Lyudmila Korshukov, Ilya Kabildina, Naylya Sirota, Valentina Zhumaliyeva, Vera Taizhanova, Dana Vazenmiller, Dmitriy Turmukhambetova, Anar Association of four genetic variants with colorectal cancer in Kazakhstan population |
title | Association of four genetic variants with colorectal cancer in Kazakhstan population |
title_full | Association of four genetic variants with colorectal cancer in Kazakhstan population |
title_fullStr | Association of four genetic variants with colorectal cancer in Kazakhstan population |
title_full_unstemmed | Association of four genetic variants with colorectal cancer in Kazakhstan population |
title_short | Association of four genetic variants with colorectal cancer in Kazakhstan population |
title_sort | association of four genetic variants with colorectal cancer in kazakhstan population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522836/ https://www.ncbi.nlm.nih.gov/pubmed/34676053 http://dx.doi.org/10.18632/oncotarget.28070 |
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