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Association of four genetic variants with colorectal cancer in Kazakhstan population

The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudi...

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Autores principales: Kolesnikova, Yevgeniya, Babenko, Dmitriy, Kadyrova, Irina, Kolesnichenko, Svetlana, Akhmaltdinova, Lyudmila, Korshukov, Ilya, Kabildina, Naylya, Sirota, Valentina, Zhumaliyeva, Vera, Taizhanova, Dana, Vazenmiller, Dmitriy, Turmukhambetova, Anar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522836/
https://www.ncbi.nlm.nih.gov/pubmed/34676053
http://dx.doi.org/10.18632/oncotarget.28070
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author Kolesnikova, Yevgeniya
Babenko, Dmitriy
Kadyrova, Irina
Kolesnichenko, Svetlana
Akhmaltdinova, Lyudmila
Korshukov, Ilya
Kabildina, Naylya
Sirota, Valentina
Zhumaliyeva, Vera
Taizhanova, Dana
Vazenmiller, Dmitriy
Turmukhambetova, Anar
author_facet Kolesnikova, Yevgeniya
Babenko, Dmitriy
Kadyrova, Irina
Kolesnichenko, Svetlana
Akhmaltdinova, Lyudmila
Korshukov, Ilya
Kabildina, Naylya
Sirota, Valentina
Zhumaliyeva, Vera
Taizhanova, Dana
Vazenmiller, Dmitriy
Turmukhambetova, Anar
author_sort Kolesnikova, Yevgeniya
collection PubMed
description The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudio 12K Flex PCR. For four significant SNPs inheritance model analysis was performed. Increasing risk of CRC was noted for rs10795668 in log-additive model (OR = 1.45, 95% CI: 1.05–1.99, p = 0.023); for rs1035209 in log-additive model (OR = 1.79, 95% CI: 1.18–2.72, p = 0.003); for rs11190164 in log-additive model (OR = 1.67, 95% CI: 1.17–2.38, p = 0.004). Decreasing risk of CRC was noted for rs10506868 in log-additive model (OR = 0.56, 95% CI: 0.37–0.85, p = 0.006). We detected SNPs that are associated with CRC risk in the Kazakhstan population.
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spelling pubmed-85228362021-10-20 Association of four genetic variants with colorectal cancer in Kazakhstan population Kolesnikova, Yevgeniya Babenko, Dmitriy Kadyrova, Irina Kolesnichenko, Svetlana Akhmaltdinova, Lyudmila Korshukov, Ilya Kabildina, Naylya Sirota, Valentina Zhumaliyeva, Vera Taizhanova, Dana Vazenmiller, Dmitriy Turmukhambetova, Anar Oncotarget Research Paper The study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudio 12K Flex PCR. For four significant SNPs inheritance model analysis was performed. Increasing risk of CRC was noted for rs10795668 in log-additive model (OR = 1.45, 95% CI: 1.05–1.99, p = 0.023); for rs1035209 in log-additive model (OR = 1.79, 95% CI: 1.18–2.72, p = 0.003); for rs11190164 in log-additive model (OR = 1.67, 95% CI: 1.17–2.38, p = 0.004). Decreasing risk of CRC was noted for rs10506868 in log-additive model (OR = 0.56, 95% CI: 0.37–0.85, p = 0.006). We detected SNPs that are associated with CRC risk in the Kazakhstan population. Impact Journals LLC 2021-10-12 /pmc/articles/PMC8522836/ /pubmed/34676053 http://dx.doi.org/10.18632/oncotarget.28070 Text en Copyright: © 2021 Kolesnikova et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Kolesnikova, Yevgeniya
Babenko, Dmitriy
Kadyrova, Irina
Kolesnichenko, Svetlana
Akhmaltdinova, Lyudmila
Korshukov, Ilya
Kabildina, Naylya
Sirota, Valentina
Zhumaliyeva, Vera
Taizhanova, Dana
Vazenmiller, Dmitriy
Turmukhambetova, Anar
Association of four genetic variants with colorectal cancer in Kazakhstan population
title Association of four genetic variants with colorectal cancer in Kazakhstan population
title_full Association of four genetic variants with colorectal cancer in Kazakhstan population
title_fullStr Association of four genetic variants with colorectal cancer in Kazakhstan population
title_full_unstemmed Association of four genetic variants with colorectal cancer in Kazakhstan population
title_short Association of four genetic variants with colorectal cancer in Kazakhstan population
title_sort association of four genetic variants with colorectal cancer in kazakhstan population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522836/
https://www.ncbi.nlm.nih.gov/pubmed/34676053
http://dx.doi.org/10.18632/oncotarget.28070
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