In vitro teratogenicity testing using a 3D, embryo-like gastruloid system

Pharmaceuticals intended for use in patients of childbearing potential need to be tested for teratogenicity before marketing. Several pharmaceutical companies use animal-free in vitro models which allow a more rapid selection of lead compounds and contribute to 3Rs principles (‘replace, reduce and r...

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Detalles Bibliográficos
Autores principales: Mantziou, Veronika, Baillie-Benson, Peter, Jaklin, Manuela, Kustermann, Stefan, Arias, Alfonso Martínez, Moris, Naomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon In Cooperation With The Reproductive Toxicology Center 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522962/
https://www.ncbi.nlm.nih.gov/pubmed/34425190
http://dx.doi.org/10.1016/j.reprotox.2021.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522962/
https://www.ncbi.nlm.nih.gov/pubmed/34425190
http://dx.doi.org/10.1016/j.reprotox.2021.08.003

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