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In vitro teratogenicity testing using a 3D, embryo-like gastruloid system
Pharmaceuticals intended for use in patients of childbearing potential need to be tested for teratogenicity before marketing. Several pharmaceutical companies use animal-free in vitro models which allow a more rapid selection of lead compounds and contribute to 3Rs principles (‘replace, reduce and r...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Pergamon In Cooperation With The Reproductive Toxicology Center
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522962/ https://www.ncbi.nlm.nih.gov/pubmed/34425190 http://dx.doi.org/10.1016/j.reprotox.2021.08.003 |