HFE protein impact on iron metabolism

Hereditary hemochromatosis type 1 is an autosomal recessive disorder caused by HFE gene mutations, which is an iron homeostasis metabolism controlling co-factor. Adults with male predomination present with clinical symptoms derived by iron overload in organs. The phenotype expression is individual w...

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Detalles Bibliográficos
Autores principales: Kaczorowska-Hać, Barbara, Kaczor, Jan Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2017
Materias:
Review Article/Praca Poglądowa
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522971/
https://www.ncbi.nlm.nih.gov/pubmed/28796976
http://dx.doi.org/10.34763/devperiodmed.20172102.8590
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author Kaczorowska-Hać, Barbara
Kaczor, Jan Jacek
author_facet Kaczorowska-Hać, Barbara
Kaczor, Jan Jacek
author_sort Kaczorowska-Hać, Barbara
collection PubMed
description Hereditary hemochromatosis type 1 is an autosomal recessive disorder caused by HFE gene mutations, which is an iron homeostasis metabolism controlling co-factor. Adults with male predomination present with clinical symptoms derived by iron overload in organs. The phenotype expression is individual with an influence of individual and environmental factors. Despite the fact that HFE variants are widespread, its impact still remains unknown. The article reviews the literature considering the role of HFE gene mutations regarding its impact in children.
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spelling pubmed-85229712021-11-19 HFE protein impact on iron metabolism Kaczorowska-Hać, Barbara Kaczor, Jan Jacek Dev Period Med Review Article/Praca Poglądowa Hereditary hemochromatosis type 1 is an autosomal recessive disorder caused by HFE gene mutations, which is an iron homeostasis metabolism controlling co-factor. Adults with male predomination present with clinical symptoms derived by iron overload in organs. The phenotype expression is individual with an influence of individual and environmental factors. Despite the fact that HFE variants are widespread, its impact still remains unknown. The article reviews the literature considering the role of HFE gene mutations regarding its impact in children. Sciendo 2017-08-11 /pmc/articles/PMC8522971/ /pubmed/28796976 http://dx.doi.org/10.34763/devperiodmed.20172102.8590 Text en © 2017 Barbara Kaczorowska-Hać, Jan Jacek Kaczor, published by Sciendo https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Review Article/Praca Poglądowa
Kaczorowska-Hać, Barbara
Kaczor, Jan Jacek
HFE protein impact on iron metabolism
title HFE protein impact on iron metabolism
title_full HFE protein impact on iron metabolism
title_fullStr HFE protein impact on iron metabolism
title_full_unstemmed HFE protein impact on iron metabolism
title_short HFE protein impact on iron metabolism
title_sort hfe protein impact on iron metabolism
topic Review Article/Praca Poglądowa
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522971/
https://www.ncbi.nlm.nih.gov/pubmed/28796976
http://dx.doi.org/10.34763/devperiodmed.20172102.8590
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