The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains has been widely studied, the mechanism by which mRN...

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Detalles Bibliográficos
Autores principales: Rengifo-Gonzalez, Juan Carlos, El Hage, Krystel, Clément, Marie-Jeanne, Steiner, Emilie, Joshi, Vandana, Craveur, Pierrick, Durand, Dominique, Pastré, David, Bouhss, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523171/
https://www.ncbi.nlm.nih.gov/pubmed/34490845
http://dx.doi.org/10.7554/eLife.67605

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