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Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study

PURPOSE: The accurate differentiation between benign and malignant biliary stricture is significant but challenging. Tissue diagnosis of biliary stricture by endoscopy sampling can provide excellent specificity but insufficient sensitivity. For patients with suspected malignant biliary stricture (MB...

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Autores principales: Zhang, Yizhen, Jiang, Qingwei, Wang, Qiang, Feng, Yunlu, Wu, Dongsheng, Guo, Tao, Zhang, Shengyu, Chen, Xi, Yang, Yingyun, Shi, Wen, Wu, Xi, Yang, Aiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523316/
https://www.ncbi.nlm.nih.gov/pubmed/34675669
http://dx.doi.org/10.2147/CMAR.S333333
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author Zhang, Yizhen
Jiang, Qingwei
Wang, Qiang
Feng, Yunlu
Wu, Dongsheng
Guo, Tao
Zhang, Shengyu
Chen, Xi
Yang, Yingyun
Shi, Wen
Wu, Xi
Yang, Aiming
author_facet Zhang, Yizhen
Jiang, Qingwei
Wang, Qiang
Feng, Yunlu
Wu, Dongsheng
Guo, Tao
Zhang, Shengyu
Chen, Xi
Yang, Yingyun
Shi, Wen
Wu, Xi
Yang, Aiming
author_sort Zhang, Yizhen
collection PubMed
description PURPOSE: The accurate differentiation between benign and malignant biliary stricture is significant but challenging. Tissue diagnosis of biliary stricture by endoscopy sampling can provide excellent specificity but insufficient sensitivity. For patients with suspected malignant biliary stricture (MBS) but non-malignant was reported in endoscopy tissue samples, we constructed a nomogram to predict malignancy and improve the overall diagnostic performance. PATIENTS AND METHODS: 232 patients with suspected MBS and underwent endoscopy tissue sampling from January 2017 to December 2019 were included, among which 123 patients’ endoscopy tissue samples were classified as non-malignant (including atypical, negative for malignancy, and nondiagnostic). Demographics, serum markers, radiological and sampling results of these 123 patients were collected to construct a nomogram using multivariate analysis. RESULTS: The nomogram was developed based on bilirubin, CA19-9, radiological result, and atypical sampling results and provided an AUC of 0.863 (95% CI 0.795–0.930) for predicting MBS. The specificity, sensitivity, and accuracy of endoscopy tissue diagnosis were 100.00%, 59.90%, and 68.53%, respectively. With the nomogram added, the overall diagnosis specificity, sensitivity, and accuracy were 95.24%, 89.20%, and 90.23%, respectively. CONCLUSION: The nomogram can predict malignancy in patients whose endoscopy tissue diagnoses were non-malignant. The overall diagnostic performance was improved with the nomogram added.
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spelling pubmed-85233162021-10-20 Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study Zhang, Yizhen Jiang, Qingwei Wang, Qiang Feng, Yunlu Wu, Dongsheng Guo, Tao Zhang, Shengyu Chen, Xi Yang, Yingyun Shi, Wen Wu, Xi Yang, Aiming Cancer Manag Res Original Research PURPOSE: The accurate differentiation between benign and malignant biliary stricture is significant but challenging. Tissue diagnosis of biliary stricture by endoscopy sampling can provide excellent specificity but insufficient sensitivity. For patients with suspected malignant biliary stricture (MBS) but non-malignant was reported in endoscopy tissue samples, we constructed a nomogram to predict malignancy and improve the overall diagnostic performance. PATIENTS AND METHODS: 232 patients with suspected MBS and underwent endoscopy tissue sampling from January 2017 to December 2019 were included, among which 123 patients’ endoscopy tissue samples were classified as non-malignant (including atypical, negative for malignancy, and nondiagnostic). Demographics, serum markers, radiological and sampling results of these 123 patients were collected to construct a nomogram using multivariate analysis. RESULTS: The nomogram was developed based on bilirubin, CA19-9, radiological result, and atypical sampling results and provided an AUC of 0.863 (95% CI 0.795–0.930) for predicting MBS. The specificity, sensitivity, and accuracy of endoscopy tissue diagnosis were 100.00%, 59.90%, and 68.53%, respectively. With the nomogram added, the overall diagnosis specificity, sensitivity, and accuracy were 95.24%, 89.20%, and 90.23%, respectively. CONCLUSION: The nomogram can predict malignancy in patients whose endoscopy tissue diagnoses were non-malignant. The overall diagnostic performance was improved with the nomogram added. Dove 2021-10-11 /pmc/articles/PMC8523316/ /pubmed/34675669 http://dx.doi.org/10.2147/CMAR.S333333 Text en © 2021 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhang, Yizhen
Jiang, Qingwei
Wang, Qiang
Feng, Yunlu
Wu, Dongsheng
Guo, Tao
Zhang, Shengyu
Chen, Xi
Yang, Yingyun
Shi, Wen
Wu, Xi
Yang, Aiming
Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study
title Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study
title_full Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study
title_fullStr Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study
title_full_unstemmed Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study
title_short Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study
title_sort predicting malignancy of biliary stricture with a nomogram in patients with a non-malignant endoscopic tissue diagnosis: a retrospective study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523316/
https://www.ncbi.nlm.nih.gov/pubmed/34675669
http://dx.doi.org/10.2147/CMAR.S333333
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