Immune regulation in renal inflammation

Renal inflammation, induced by autoantigen recognition or toxic drugs, leads to renal tissue injury and decline in kidney function. Recent studies have demonstrated the crucial role for regulatory T cells in suppressing pathogenic adaptive but also innate immune responses in the inflamed kidney. How...

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Detalles Bibliográficos
Autores principales: Neumann, Katrin, Tiegs, Gisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523435/
https://www.ncbi.nlm.nih.gov/pubmed/33496881
http://dx.doi.org/10.1007/s00441-020-03351-1
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author Neumann, Katrin
Tiegs, Gisa
author_facet Neumann, Katrin
Tiegs, Gisa
author_sort Neumann, Katrin
collection PubMed
description Renal inflammation, induced by autoantigen recognition or toxic drugs, leads to renal tissue injury and decline in kidney function. Recent studies have demonstrated the crucial role for regulatory T cells in suppressing pathogenic adaptive but also innate immune responses in the inflamed kidney. However, there is also evidence for other immune cell populations with immunosuppressive function in renal inflammation. This review summarizes mechanisms of immune cell regulation in immune-mediated glomerulonephritis and acute and chronic nephrotoxicity.
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spelling pubmed-85234352021-11-04 Immune regulation in renal inflammation Neumann, Katrin Tiegs, Gisa Cell Tissue Res Review Renal inflammation, induced by autoantigen recognition or toxic drugs, leads to renal tissue injury and decline in kidney function. Recent studies have demonstrated the crucial role for regulatory T cells in suppressing pathogenic adaptive but also innate immune responses in the inflamed kidney. However, there is also evidence for other immune cell populations with immunosuppressive function in renal inflammation. This review summarizes mechanisms of immune cell regulation in immune-mediated glomerulonephritis and acute and chronic nephrotoxicity. Springer Berlin Heidelberg 2021-01-26 2021 /pmc/articles/PMC8523435/ /pubmed/33496881 http://dx.doi.org/10.1007/s00441-020-03351-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Neumann, Katrin
Tiegs, Gisa
Immune regulation in renal inflammation
title Immune regulation in renal inflammation
title_full Immune regulation in renal inflammation
title_fullStr Immune regulation in renal inflammation
title_full_unstemmed Immune regulation in renal inflammation
title_short Immune regulation in renal inflammation
title_sort immune regulation in renal inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523435/
https://www.ncbi.nlm.nih.gov/pubmed/33496881
http://dx.doi.org/10.1007/s00441-020-03351-1
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