Immune-mediated entities of (primary) focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) represents a glomerular scar formation downstream of various different mechanisms leading to podocytopathy and podocyte loss. Recently, significant advances were made in understanding genetic factors, podocyte intrinsic mechanisms, and adaptive mechanisms ca...

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Detalles Bibliográficos
Autores principales: Braun, Fabian, Homeyer, Inka, Alachkar, Nada, Huber, Tobias B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523460/
https://www.ncbi.nlm.nih.gov/pubmed/33907872
http://dx.doi.org/10.1007/s00441-021-03454-3
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author Braun, Fabian
Homeyer, Inka
Alachkar, Nada
Huber, Tobias B.
author_facet Braun, Fabian
Homeyer, Inka
Alachkar, Nada
Huber, Tobias B.
author_sort Braun, Fabian
collection PubMed
description Focal segmental glomerulosclerosis (FSGS) represents a glomerular scar formation downstream of various different mechanisms leading to podocytopathy and podocyte loss. Recently, significant advances were made in understanding genetic factors, podocyte intrinsic mechanisms, and adaptive mechanisms causing FSGS. However, while most cases of nephrotic FSGS are being treated with immunosuppressants, the underlying immune dysregulation, involved immune cells, and soluble factors are only incompletely understood. Thus, we here summarize the current knowledge of proposed immune effector cells, secreted soluble factors, and podocyte response in immune-mediated (primary) FSGS.
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spelling pubmed-85234602021-11-04 Immune-mediated entities of (primary) focal segmental glomerulosclerosis Braun, Fabian Homeyer, Inka Alachkar, Nada Huber, Tobias B. Cell Tissue Res Review Focal segmental glomerulosclerosis (FSGS) represents a glomerular scar formation downstream of various different mechanisms leading to podocytopathy and podocyte loss. Recently, significant advances were made in understanding genetic factors, podocyte intrinsic mechanisms, and adaptive mechanisms causing FSGS. However, while most cases of nephrotic FSGS are being treated with immunosuppressants, the underlying immune dysregulation, involved immune cells, and soluble factors are only incompletely understood. Thus, we here summarize the current knowledge of proposed immune effector cells, secreted soluble factors, and podocyte response in immune-mediated (primary) FSGS. Springer Berlin Heidelberg 2021-04-27 2021 /pmc/articles/PMC8523460/ /pubmed/33907872 http://dx.doi.org/10.1007/s00441-021-03454-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Braun, Fabian
Homeyer, Inka
Alachkar, Nada
Huber, Tobias B.
Immune-mediated entities of (primary) focal segmental glomerulosclerosis
title Immune-mediated entities of (primary) focal segmental glomerulosclerosis
title_full Immune-mediated entities of (primary) focal segmental glomerulosclerosis
title_fullStr Immune-mediated entities of (primary) focal segmental glomerulosclerosis
title_full_unstemmed Immune-mediated entities of (primary) focal segmental glomerulosclerosis
title_short Immune-mediated entities of (primary) focal segmental glomerulosclerosis
title_sort immune-mediated entities of (primary) focal segmental glomerulosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523460/
https://www.ncbi.nlm.nih.gov/pubmed/33907872
http://dx.doi.org/10.1007/s00441-021-03454-3
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