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Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation

Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate that prophyl...

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Autores principales: Verma, Anil, Hawes, Chase E., Lakshmanappa, Yashavanth Shaan, Roh, Jamin W., Schmidt, Brian A., Dutra, Joseph, Louie, William, Liu, Hongwei, Ma, Zhong-Min, Watanabe, Jennifer K., Usachenko, Jodie L., Immareddy, Ramya, Sammak, Rebecca L., Pollard, Rachel, Reader, J. Rachel, Olstad, Katherine J., Coffey, Lark L., Kozlowski, Pamela A., Hartigan-O’Connor, Dennis J., Nussenzweig, Michel, Van Rompay, Koen K.A., Morrison, John H., Iyer, Smita S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523485/
https://www.ncbi.nlm.nih.gov/pubmed/34706272
http://dx.doi.org/10.1016/j.celrep.2021.109942
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author Verma, Anil
Hawes, Chase E.
Lakshmanappa, Yashavanth Shaan
Roh, Jamin W.
Schmidt, Brian A.
Dutra, Joseph
Louie, William
Liu, Hongwei
Ma, Zhong-Min
Watanabe, Jennifer K.
Usachenko, Jodie L.
Immareddy, Ramya
Sammak, Rebecca L.
Pollard, Rachel
Reader, J. Rachel
Olstad, Katherine J.
Coffey, Lark L.
Kozlowski, Pamela A.
Hartigan-O’Connor, Dennis J.
Nussenzweig, Michel
Van Rompay, Koen K.A.
Morrison, John H.
Iyer, Smita S.
author_facet Verma, Anil
Hawes, Chase E.
Lakshmanappa, Yashavanth Shaan
Roh, Jamin W.
Schmidt, Brian A.
Dutra, Joseph
Louie, William
Liu, Hongwei
Ma, Zhong-Min
Watanabe, Jennifer K.
Usachenko, Jodie L.
Immareddy, Ramya
Sammak, Rebecca L.
Pollard, Rachel
Reader, J. Rachel
Olstad, Katherine J.
Coffey, Lark L.
Kozlowski, Pamela A.
Hartigan-O’Connor, Dennis J.
Nussenzweig, Michel
Van Rompay, Koen K.A.
Morrison, John H.
Iyer, Smita S.
author_sort Verma, Anil
collection PubMed
description Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate that prophylactic mAb treatment blocks viral replication in both the upper and lower respiratory tracts in aged, type 2 diabetic rhesus macaques. mAb infusion dramatically curtails severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated stimulation of interferon-induced chemokines and T cell activation, significantly reducing development of interstitial pneumonia. Furthermore, mAb infusion significantly dampens the greater than 3-fold increase in SARS-CoV-2-induced effector CD4 T cell influx into the cerebrospinal fluid. Our data show that neutralizing mAbs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
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spelling pubmed-85234852021-10-20 Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation Verma, Anil Hawes, Chase E. Lakshmanappa, Yashavanth Shaan Roh, Jamin W. Schmidt, Brian A. Dutra, Joseph Louie, William Liu, Hongwei Ma, Zhong-Min Watanabe, Jennifer K. Usachenko, Jodie L. Immareddy, Ramya Sammak, Rebecca L. Pollard, Rachel Reader, J. Rachel Olstad, Katherine J. Coffey, Lark L. Kozlowski, Pamela A. Hartigan-O’Connor, Dennis J. Nussenzweig, Michel Van Rompay, Koen K.A. Morrison, John H. Iyer, Smita S. Cell Rep Report Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate that prophylactic mAb treatment blocks viral replication in both the upper and lower respiratory tracts in aged, type 2 diabetic rhesus macaques. mAb infusion dramatically curtails severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated stimulation of interferon-induced chemokines and T cell activation, significantly reducing development of interstitial pneumonia. Furthermore, mAb infusion significantly dampens the greater than 3-fold increase in SARS-CoV-2-induced effector CD4 T cell influx into the cerebrospinal fluid. Our data show that neutralizing mAbs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure. Cell Press 2021-11-02 2021-10-19 /pmc/articles/PMC8523485/ /pubmed/34706272 http://dx.doi.org/10.1016/j.celrep.2021.109942 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Report
Verma, Anil
Hawes, Chase E.
Lakshmanappa, Yashavanth Shaan
Roh, Jamin W.
Schmidt, Brian A.
Dutra, Joseph
Louie, William
Liu, Hongwei
Ma, Zhong-Min
Watanabe, Jennifer K.
Usachenko, Jodie L.
Immareddy, Ramya
Sammak, Rebecca L.
Pollard, Rachel
Reader, J. Rachel
Olstad, Katherine J.
Coffey, Lark L.
Kozlowski, Pamela A.
Hartigan-O’Connor, Dennis J.
Nussenzweig, Michel
Van Rompay, Koen K.A.
Morrison, John H.
Iyer, Smita S.
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
title Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
title_full Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
title_fullStr Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
title_full_unstemmed Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
title_short Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
title_sort monoclonal antibodies protect aged rhesus macaques from sars-cov-2-induced immune activation and neuroinflammation
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523485/
https://www.ncbi.nlm.nih.gov/pubmed/34706272
http://dx.doi.org/10.1016/j.celrep.2021.109942
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