Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer

Aberrant activation of endoplasmic reticulum (ER) stress by extrinsic and intrinsic factors contributes to tumorigenesis and resistance to chemotherapies in various cancer types. Our previous studies have shown that the downregulation of PHLPP, a novel family of Ser/Thr protein phosphatases, promote...

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Detalles Bibliográficos
Autores principales: Guo, Bianqin, Xiong, Xiaopeng, Hasani, Sumati, Wen, Yang-An, Li, Austin T., Martinez, Rebecca, Skaggs, Ashley T., Gao, Tianyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523518/
https://www.ncbi.nlm.nih.gov/pubmed/34663797
http://dx.doi.org/10.1038/s41419-021-04251-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523518/
https://www.ncbi.nlm.nih.gov/pubmed/34663797
http://dx.doi.org/10.1038/s41419-021-04251-0

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