Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis

DNA (cytosine-5)-methyltransferase 3A (DNMT3A) mutations occur in ~20% of de novo acute myeloid leukemia (AML) patients, and >50% of these mutations in AML samples are heterozygous missense alterations within the methyltransferase domain at residue R882. DNMT3A R882 mutations in AML patients prom...

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Detalles Bibliográficos
Autores principales: Liao, Min, Dong, Qiongye, Chen, Ruiqing, Xu, Liqian, Jiang, Yuxuan, Guo, Zhenxing, Xiao, Min, He, Wei, Cao, Changcai, Hu, Ronghua, Sun, Wanling, Jiang, Hong, Wang, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523644/
https://www.ncbi.nlm.nih.gov/pubmed/34663800
http://dx.doi.org/10.1038/s41420-021-00697-5

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