Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain V(H)H antibodies

The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain V(H)H antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they are single-domain proteins. In this work, base...

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Detalles Bibliográficos
Autores principales: Ikeuchi, Emina, Kuroda, Daisuke, Nakakido, Makoto, Murakami, Akikazu, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523659/
https://www.ncbi.nlm.nih.gov/pubmed/34663870
http://dx.doi.org/10.1038/s41598-021-98977-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523659/
https://www.ncbi.nlm.nih.gov/pubmed/34663870
http://dx.doi.org/10.1038/s41598-021-98977-8

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