Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

Polygenic risk prediction is a widely investigated topic because of its promising clinical applications. Genetic variants in functional regions of the genome are enriched for complex trait heritability. Here, we introduce a method for polygenic prediction, LDpred-funct, that leverages trait-specific...

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Detalles Bibliográficos
Autores principales: Márquez-Luna, Carla, Gazal, Steven, Loh, Po-Ru, Kim, Samuel S., Furlotte, Nicholas, Auton, Adam, Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523709/
https://www.ncbi.nlm.nih.gov/pubmed/34663819
http://dx.doi.org/10.1038/s41467-021-25171-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523709/
https://www.ncbi.nlm.nih.gov/pubmed/34663819
http://dx.doi.org/10.1038/s41467-021-25171-9

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