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Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets

Polygenic risk prediction is a widely investigated topic because of its promising clinical applications. Genetic variants in functional regions of the genome are enriched for complex trait heritability. Here, we introduce a method for polygenic prediction, LDpred-funct, that leverages trait-specific...

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Detalles Bibliográficos
Autores principales:	Márquez-Luna, Carla, Gazal, Steven, Loh, Po-Ru, Kim, Samuel S., Furlotte, Nicholas, Auton, Adam, Price, Alkes L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523709/ https://www.ncbi.nlm.nih.gov/pubmed/34663819 http://dx.doi.org/10.1038/s41467-021-25171-9

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