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Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions

More than 90% of surgical patients develop postoperative adhesions, and the incidence of hospital re-admissions can be as high as 20%. Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions. To solve this clinic...

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Autores principales: Ruiz-Esparza, Guillermo U., Wang, Xichi, Zhang, Xingcai, Jimenez-Vazquez, Sofia, Diaz-Gomez, Liliana, Lavoie, Anne-Marie, Afewerki, Samson, Fuentes-Baldemar, Andres A., Parra-Saldivar, Roberto, Jiang, Nan, Annabi, Nasim, Saleh, Bahram, Yetisen, Ali K., Sheikhi, Amir, Jozefiak, Thomas H., Shin, Su Ryon, Dong, Nianguo, Khademhosseini, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523737/
https://www.ncbi.nlm.nih.gov/pubmed/34664123
http://dx.doi.org/10.1007/s40820-021-00712-5
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author Ruiz-Esparza, Guillermo U.
Wang, Xichi
Zhang, Xingcai
Jimenez-Vazquez, Sofia
Diaz-Gomez, Liliana
Lavoie, Anne-Marie
Afewerki, Samson
Fuentes-Baldemar, Andres A.
Parra-Saldivar, Roberto
Jiang, Nan
Annabi, Nasim
Saleh, Bahram
Yetisen, Ali K.
Sheikhi, Amir
Jozefiak, Thomas H.
Shin, Su Ryon
Dong, Nianguo
Khademhosseini, Ali
author_facet Ruiz-Esparza, Guillermo U.
Wang, Xichi
Zhang, Xingcai
Jimenez-Vazquez, Sofia
Diaz-Gomez, Liliana
Lavoie, Anne-Marie
Afewerki, Samson
Fuentes-Baldemar, Andres A.
Parra-Saldivar, Roberto
Jiang, Nan
Annabi, Nasim
Saleh, Bahram
Yetisen, Ali K.
Sheikhi, Amir
Jozefiak, Thomas H.
Shin, Su Ryon
Dong, Nianguo
Khademhosseini, Ali
author_sort Ruiz-Esparza, Guillermo U.
collection PubMed
description More than 90% of surgical patients develop postoperative adhesions, and the incidence of hospital re-admissions can be as high as 20%. Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions. To solve this clinical limitation, we developed an injectable and sprayable shear-thinning hydrogel barrier (STHB) composed of silicate nanoplatelets and poly(ethylene oxide). We optimized this technology to recover mechanical integrity after stress, enabling its delivery though injectable and sprayable methods. We also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in vitro. The STHB was then tested in a rodent model of peritoneal injury to determine its efficacy preventing the formation of postoperative adhesions. After two weeks, the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions, and STHB formulations presented superior efficacy compared to a commercially available adhesion barrier. Histological and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB formulations. Our technology demonstrated increased efficacy, ease of use in complex anatomies, and compatibility with different delivery methods, providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40820-021-00712-5.
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spelling pubmed-85237372021-11-04 Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions Ruiz-Esparza, Guillermo U. Wang, Xichi Zhang, Xingcai Jimenez-Vazquez, Sofia Diaz-Gomez, Liliana Lavoie, Anne-Marie Afewerki, Samson Fuentes-Baldemar, Andres A. Parra-Saldivar, Roberto Jiang, Nan Annabi, Nasim Saleh, Bahram Yetisen, Ali K. Sheikhi, Amir Jozefiak, Thomas H. Shin, Su Ryon Dong, Nianguo Khademhosseini, Ali Nanomicro Lett Article More than 90% of surgical patients develop postoperative adhesions, and the incidence of hospital re-admissions can be as high as 20%. Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions. To solve this clinical limitation, we developed an injectable and sprayable shear-thinning hydrogel barrier (STHB) composed of silicate nanoplatelets and poly(ethylene oxide). We optimized this technology to recover mechanical integrity after stress, enabling its delivery though injectable and sprayable methods. We also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in vitro. The STHB was then tested in a rodent model of peritoneal injury to determine its efficacy preventing the formation of postoperative adhesions. After two weeks, the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions, and STHB formulations presented superior efficacy compared to a commercially available adhesion barrier. Histological and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB formulations. Our technology demonstrated increased efficacy, ease of use in complex anatomies, and compatibility with different delivery methods, providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40820-021-00712-5. Springer Nature Singapore 2021-10-18 /pmc/articles/PMC8523737/ /pubmed/34664123 http://dx.doi.org/10.1007/s40820-021-00712-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ruiz-Esparza, Guillermo U.
Wang, Xichi
Zhang, Xingcai
Jimenez-Vazquez, Sofia
Diaz-Gomez, Liliana
Lavoie, Anne-Marie
Afewerki, Samson
Fuentes-Baldemar, Andres A.
Parra-Saldivar, Roberto
Jiang, Nan
Annabi, Nasim
Saleh, Bahram
Yetisen, Ali K.
Sheikhi, Amir
Jozefiak, Thomas H.
Shin, Su Ryon
Dong, Nianguo
Khademhosseini, Ali
Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions
title Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions
title_full Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions
title_fullStr Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions
title_full_unstemmed Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions
title_short Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions
title_sort nanoengineered shear-thinning hydrogel barrier for preventing postoperative abdominal adhesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523737/
https://www.ncbi.nlm.nih.gov/pubmed/34664123
http://dx.doi.org/10.1007/s40820-021-00712-5
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