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Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis

Objective: This two-sample Mendelian randomization (MR) study aimed to examine the potential causal association of telomere length (TL) with the risk of osteoarthritis (OA). Method: The summary-level data for OA was derived from the United Kingdom Biobank cohort, including 50,508 individuals of Euro...

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Autores principales: Yang, Jing, Xu, Huiqing, Cai, Bingyue, Wei, Jiahe, Sun, Lingling, Li, Yasong, Wang, Tianle, Li, Yingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523818/
https://www.ncbi.nlm.nih.gov/pubmed/34675961
http://dx.doi.org/10.3389/fgene.2021.718890
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author Yang, Jing
Xu, Huiqing
Cai, Bingyue
Wei, Jiahe
Sun, Lingling
Li, Yasong
Wang, Tianle
Li, Yingjun
author_facet Yang, Jing
Xu, Huiqing
Cai, Bingyue
Wei, Jiahe
Sun, Lingling
Li, Yasong
Wang, Tianle
Li, Yingjun
author_sort Yang, Jing
collection PubMed
description Objective: This two-sample Mendelian randomization (MR) study aimed to examine the potential causal association of telomere length (TL) with the risk of osteoarthritis (OA). Method: The summary-level data for OA was derived from the United Kingdom Biobank cohort, including 50,508 individuals of European descent. Eighteen single nucleotide polymorphisms associated with TL were identified as instrumental variables from the most up-to-date TL genome-wide association study (GWAS) involving over 78,592 individuals of European descent. Based on the GWASs data, MR was performed using established statistical analysis methods including the inverse variance weighted, weighted median, MR-Egger, and MR pleiotropy residual sum and outlier. Results: Genetically determined TL was not associated with the risk of total OA (IVW odds ratio [OR] = 1.00, 95% confidence interval [CI] = 0.83, 1.21). In subgroup analyses stratified by OA site, no evidence in favor of association between genetically determined TL and knee OA was found (IVW OR = 1.18, 95% CI = 0.89, 1.58). However, using WM method, we observed a limited protective effect of longer TL on the risk of hip OA (OR = 0.60, 95% CI = 0.36–0.99), whereas the results of the IVW (p = 0.931) and MR-PRESSO (p = 0.932) showed that TL had no effect on hip OA. Conclusions: This study does not support a causal association between TL and total OA. A potential protective association between longer TL and hip OA, though possible, remains less certain.
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spelling pubmed-85238182021-10-20 Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis Yang, Jing Xu, Huiqing Cai, Bingyue Wei, Jiahe Sun, Lingling Li, Yasong Wang, Tianle Li, Yingjun Front Genet Genetics Objective: This two-sample Mendelian randomization (MR) study aimed to examine the potential causal association of telomere length (TL) with the risk of osteoarthritis (OA). Method: The summary-level data for OA was derived from the United Kingdom Biobank cohort, including 50,508 individuals of European descent. Eighteen single nucleotide polymorphisms associated with TL were identified as instrumental variables from the most up-to-date TL genome-wide association study (GWAS) involving over 78,592 individuals of European descent. Based on the GWASs data, MR was performed using established statistical analysis methods including the inverse variance weighted, weighted median, MR-Egger, and MR pleiotropy residual sum and outlier. Results: Genetically determined TL was not associated with the risk of total OA (IVW odds ratio [OR] = 1.00, 95% confidence interval [CI] = 0.83, 1.21). In subgroup analyses stratified by OA site, no evidence in favor of association between genetically determined TL and knee OA was found (IVW OR = 1.18, 95% CI = 0.89, 1.58). However, using WM method, we observed a limited protective effect of longer TL on the risk of hip OA (OR = 0.60, 95% CI = 0.36–0.99), whereas the results of the IVW (p = 0.931) and MR-PRESSO (p = 0.932) showed that TL had no effect on hip OA. Conclusions: This study does not support a causal association between TL and total OA. A potential protective association between longer TL and hip OA, though possible, remains less certain. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8523818/ /pubmed/34675961 http://dx.doi.org/10.3389/fgene.2021.718890 Text en Copyright © 2021 Yang, Xu, Cai, Wei, Sun, Li, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Yang, Jing
Xu, Huiqing
Cai, Bingyue
Wei, Jiahe
Sun, Lingling
Li, Yasong
Wang, Tianle
Li, Yingjun
Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis
title Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis
title_full Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis
title_fullStr Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis
title_full_unstemmed Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis
title_short Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis
title_sort genetically predicted longer telomere length may reduce risk of hip osteoarthritis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523818/
https://www.ncbi.nlm.nih.gov/pubmed/34675961
http://dx.doi.org/10.3389/fgene.2021.718890
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