Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p

BACKGROUND & AIMS: Immune-mediated induction of cytidine deaminase APOBEC3B (A3B) expression leads to HBV covalently closed circular DNA (cccDNA) decay. Here, we aimed to decipher the signalling pathway(s) and regulatory mechanism(s) involved in A3B induction and related HBV control. METHODS: Di...

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Detalles Bibliográficos
Autores principales: Faure-Dupuy, Suzanne, Riedl, Tobias, Rolland, Maude, Hizir, Zoheir, Reisinger, Florian, Neuhaus, Katharina, Schuehle, Svenja, Remouchamps, Caroline, Gillet, Nicolas, Schönung, Maximilian, Stadler, Mira, Wettengel, Jochen, Barnault, Romain, Parent, Romain, Schuster, Linda Christina, Farhat, Rayan, Prokosch, Sandra, Leuchtenberger, Corinna, Öllinger, Rupert, Engleitner, Thomas, Rippe, Karsten, Rad, Roland, Unger, Kristian, Tscharahganeh, Darjus, Lipka, Daniel B., Protzer, Ulrike, Durantel, David, Lucifora, Julie, Dejardin, Emmanuel, Heikenwälder, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523871/
https://www.ncbi.nlm.nih.gov/pubmed/34704004
http://dx.doi.org/10.1016/j.jhepr.2021.100354

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