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Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass
The autoregulation of cerebral blood flow protects against brain injury from transient fluctuations in arterial blood pressure. Impaired autoregulation may contribute to hypoperfusion injury in neonates and infants. Monitoring cerebral autoregulation in neonatal cardiac surgery as a guide for arteri...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523884/ https://www.ncbi.nlm.nih.gov/pubmed/34675872 http://dx.doi.org/10.3389/fneur.2021.740185 |
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author | Spilka, Jared M. O'Halloran, Conor P. Marino, Bradley S. Brady, Kenneth M. |
author_facet | Spilka, Jared M. O'Halloran, Conor P. Marino, Bradley S. Brady, Kenneth M. |
author_sort | Spilka, Jared M. |
collection | PubMed |
description | The autoregulation of cerebral blood flow protects against brain injury from transient fluctuations in arterial blood pressure. Impaired autoregulation may contribute to hypoperfusion injury in neonates and infants. Monitoring cerebral autoregulation in neonatal cardiac surgery as a guide for arterial blood pressure management may reduce neurodevelopmental morbidity. Cerebral autoregulation monitoring has been validated in animal models and in an adult trial autoregulation monitoring during bypass improved postoperative delirium scores. The nuances of pediatric cardiac disease and congenital heart surgery make simply applying adult trial findings to this unique population inappropriate. Therefore, dedicated pediatric clinical trials of cerebral autoregulation monitoring are indicated. |
format | Online Article Text |
id | pubmed-8523884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85238842021-10-20 Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass Spilka, Jared M. O'Halloran, Conor P. Marino, Bradley S. Brady, Kenneth M. Front Neurol Neurology The autoregulation of cerebral blood flow protects against brain injury from transient fluctuations in arterial blood pressure. Impaired autoregulation may contribute to hypoperfusion injury in neonates and infants. Monitoring cerebral autoregulation in neonatal cardiac surgery as a guide for arterial blood pressure management may reduce neurodevelopmental morbidity. Cerebral autoregulation monitoring has been validated in animal models and in an adult trial autoregulation monitoring during bypass improved postoperative delirium scores. The nuances of pediatric cardiac disease and congenital heart surgery make simply applying adult trial findings to this unique population inappropriate. Therefore, dedicated pediatric clinical trials of cerebral autoregulation monitoring are indicated. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8523884/ /pubmed/34675872 http://dx.doi.org/10.3389/fneur.2021.740185 Text en Copyright © 2021 Spilka, O'Halloran, Marino and Brady. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Spilka, Jared M. O'Halloran, Conor P. Marino, Bradley S. Brady, Kenneth M. Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass |
title | Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass |
title_full | Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass |
title_fullStr | Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass |
title_full_unstemmed | Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass |
title_short | Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass |
title_sort | perspective on cerebral autoregulation monitoring in neonatal cardiac surgery requiring cardiopulmonary bypass |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523884/ https://www.ncbi.nlm.nih.gov/pubmed/34675872 http://dx.doi.org/10.3389/fneur.2021.740185 |
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