β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Currently there is a lack of tumor-selective and efficacious therapies for hepatocellular carcinoma. β-Lapachone (ARQ761 in clinical form) selectively kill NADPH: quinone oxidoreductase 1 (NQO1)-overexpressi...

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Detalles Bibliográficos
Autores principales: Zhao, Wenxiu, Jiang, Lingxiang, Fang, Ting, Fang, Fei, Liu, Yingchun, Zhao, Ye, You, Yuting, Zhou, Hao, Su, Xiaolin, Wang, Jiangwei, Liu, Sheng, Chen, Yaomin, Wan, Jun, Huang, Xiumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523939/
https://www.ncbi.nlm.nih.gov/pubmed/34676172
http://dx.doi.org/10.3389/fonc.2021.747282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523939/
https://www.ncbi.nlm.nih.gov/pubmed/34676172
http://dx.doi.org/10.3389/fonc.2021.747282

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