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Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters

PURPOSE: Explaining why (90)Y TOF-PET based equivalent uniform dose (EUD) using recommended manufacturer FDG reconstruction parameters has been shown to predict response. METHODS: The hot rods insert of a Jaszczak deluxe phantom was partially filled with a 2.65 GBq (90)Y - 300ml DTPA water solution...

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Autores principales: Hesse, Michel, d’Abadie, Philipe, Lhommel, Renaud, Jamar, Francois, Walrand, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523947/
https://www.ncbi.nlm.nih.gov/pubmed/34676157
http://dx.doi.org/10.3389/fonc.2021.592529
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author Hesse, Michel
d’Abadie, Philipe
Lhommel, Renaud
Jamar, Francois
Walrand, Stephan
author_facet Hesse, Michel
d’Abadie, Philipe
Lhommel, Renaud
Jamar, Francois
Walrand, Stephan
author_sort Hesse, Michel
collection PubMed
description PURPOSE: Explaining why (90)Y TOF-PET based equivalent uniform dose (EUD) using recommended manufacturer FDG reconstruction parameters has been shown to predict response. METHODS: The hot rods insert of a Jaszczak deluxe phantom was partially filled with a 2.65 GBq (90)Y - 300ml DTPA water solution resulting in a 100 Gy mean absorbed dose in the 6 sectors. A two bed 20min/position acquisition was performed on a 550ps- and on a 320ps- TOF-PET/CT and reconstructed with recommended manufacturer FDG reconstruction parameters, without and with additional filtering. The whole procedure was repeated on both PET after adding 300ml of water (50Gy setup). The phantom was acquired again after decay by a factor of 10 (5Gy setup), but with 200min per bed position. For comparison, the phantom was also acquired with (18)F activity corresponding to a clinical FDG whole body acquisition. RESULTS: The 100Gy-setup provided a hot rod sectors image almost as good as the (18)F phantom. However, despite acquisition time compensation, the 5Gy-setup provides much lower quality imaging. TOF-PET based sectors EUDs for the three large rod sectors agreed with the actual EUDs computed with a radiosensitivity of 0.021Gy(-1) well in the range observed in external beam radiotherapy (EBRT), i.e. 0.01-0.04Gy(-1). This agreement explains the reunification of the dose-response relationships of the glass and resin spheres in HCC using the TOF-PET based EUD. Additional filtering reduced the EUDs agreement quality. CONCLUSIONS: Recommended manufacturer FDG reconstruction parameters are suitable in TOF-PET post (90)Y liver radioembolization for accurate tumour EUD computation. The present results rule out the use of low specific activity phantom studies to optimize reconstruction parameters.
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spelling pubmed-85239472021-10-20 Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters Hesse, Michel d’Abadie, Philipe Lhommel, Renaud Jamar, Francois Walrand, Stephan Front Oncol Oncology PURPOSE: Explaining why (90)Y TOF-PET based equivalent uniform dose (EUD) using recommended manufacturer FDG reconstruction parameters has been shown to predict response. METHODS: The hot rods insert of a Jaszczak deluxe phantom was partially filled with a 2.65 GBq (90)Y - 300ml DTPA water solution resulting in a 100 Gy mean absorbed dose in the 6 sectors. A two bed 20min/position acquisition was performed on a 550ps- and on a 320ps- TOF-PET/CT and reconstructed with recommended manufacturer FDG reconstruction parameters, without and with additional filtering. The whole procedure was repeated on both PET after adding 300ml of water (50Gy setup). The phantom was acquired again after decay by a factor of 10 (5Gy setup), but with 200min per bed position. For comparison, the phantom was also acquired with (18)F activity corresponding to a clinical FDG whole body acquisition. RESULTS: The 100Gy-setup provided a hot rod sectors image almost as good as the (18)F phantom. However, despite acquisition time compensation, the 5Gy-setup provides much lower quality imaging. TOF-PET based sectors EUDs for the three large rod sectors agreed with the actual EUDs computed with a radiosensitivity of 0.021Gy(-1) well in the range observed in external beam radiotherapy (EBRT), i.e. 0.01-0.04Gy(-1). This agreement explains the reunification of the dose-response relationships of the glass and resin spheres in HCC using the TOF-PET based EUD. Additional filtering reduced the EUDs agreement quality. CONCLUSIONS: Recommended manufacturer FDG reconstruction parameters are suitable in TOF-PET post (90)Y liver radioembolization for accurate tumour EUD computation. The present results rule out the use of low specific activity phantom studies to optimize reconstruction parameters. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8523947/ /pubmed/34676157 http://dx.doi.org/10.3389/fonc.2021.592529 Text en Copyright © 2021 Hesse, d’Abadie, Lhommel, Jamar and Walrand https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Hesse, Michel
d’Abadie, Philipe
Lhommel, Renaud
Jamar, Francois
Walrand, Stephan
Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters
title Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters
title_full Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters
title_fullStr Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters
title_full_unstemmed Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters
title_short Yttrium-90 TOF-PET-Based EUD Predicts Response Post Liver Radioembolizations Using Recommended Manufacturer FDG Reconstruction Parameters
title_sort yttrium-90 tof-pet-based eud predicts response post liver radioembolizations using recommended manufacturer fdg reconstruction parameters
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523947/
https://www.ncbi.nlm.nih.gov/pubmed/34676157
http://dx.doi.org/10.3389/fonc.2021.592529
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