Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases

Accumulating evidences support that amino acids direct the fate decision of immune cells. Glycine is a simple structural amino acid acting as an inhibitory neurotransmitter. Besides, glycine receptors as well as glycine transporters are found in macrophages, indicating that glycine alters the functi...

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Autores principales: Gan, Zhending, Zhang, Meiyu, Xie, Donghui, Wu, Xiaoyan, Hong, Changming, Fu, Jian, Fan, Lijuan, Wang, Shengyi, Han, Sufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523992/
https://www.ncbi.nlm.nih.gov/pubmed/34675940
http://dx.doi.org/10.3389/fimmu.2021.762564
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author Gan, Zhending
Zhang, Meiyu
Xie, Donghui
Wu, Xiaoyan
Hong, Changming
Fu, Jian
Fan, Lijuan
Wang, Shengyi
Han, Sufang
author_facet Gan, Zhending
Zhang, Meiyu
Xie, Donghui
Wu, Xiaoyan
Hong, Changming
Fu, Jian
Fan, Lijuan
Wang, Shengyi
Han, Sufang
author_sort Gan, Zhending
collection PubMed
description Accumulating evidences support that amino acids direct the fate decision of immune cells. Glycine is a simple structural amino acid acting as an inhibitory neurotransmitter. Besides, glycine receptors as well as glycine transporters are found in macrophages, indicating that glycine alters the functions of macrophages besides as an inhibitory neurotransmitter. Mechanistically, glycine shapes macrophage polarization via cellular signaling pathways (e.g., NF-κB, NRF2, and Akt) and microRNAs. Moreover, glycine has beneficial effects in preventing and/or treating macrophage-associated diseases such as colitis, NAFLD and ischemia-reperfusion injury. Collectively, this review highlights the conceivable role of glycinergic signaling for macrophage polarization and indicates the potential application of glycine supplementation as an adjuvant therapy in macrophage-associated diseases.
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spelling pubmed-85239922021-10-20 Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases Gan, Zhending Zhang, Meiyu Xie, Donghui Wu, Xiaoyan Hong, Changming Fu, Jian Fan, Lijuan Wang, Shengyi Han, Sufang Front Immunol Immunology Accumulating evidences support that amino acids direct the fate decision of immune cells. Glycine is a simple structural amino acid acting as an inhibitory neurotransmitter. Besides, glycine receptors as well as glycine transporters are found in macrophages, indicating that glycine alters the functions of macrophages besides as an inhibitory neurotransmitter. Mechanistically, glycine shapes macrophage polarization via cellular signaling pathways (e.g., NF-κB, NRF2, and Akt) and microRNAs. Moreover, glycine has beneficial effects in preventing and/or treating macrophage-associated diseases such as colitis, NAFLD and ischemia-reperfusion injury. Collectively, this review highlights the conceivable role of glycinergic signaling for macrophage polarization and indicates the potential application of glycine supplementation as an adjuvant therapy in macrophage-associated diseases. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8523992/ /pubmed/34675940 http://dx.doi.org/10.3389/fimmu.2021.762564 Text en Copyright © 2021 Gan, Zhang, Xie, Wu, Hong, Fu, Fan, Wang and Han https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gan, Zhending
Zhang, Meiyu
Xie, Donghui
Wu, Xiaoyan
Hong, Changming
Fu, Jian
Fan, Lijuan
Wang, Shengyi
Han, Sufang
Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases
title Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases
title_full Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases
title_fullStr Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases
title_full_unstemmed Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases
title_short Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases
title_sort glycinergic signaling in macrophages and its application in macrophage-associated diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523992/
https://www.ncbi.nlm.nih.gov/pubmed/34675940
http://dx.doi.org/10.3389/fimmu.2021.762564
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