The Dynamics of B Cell Aging in Health and Disease

Aging is considered to be an important risk factor for several inflammatory diseases. B cells play a major role in chronic inflammatory diseases by antibody secretion, antigen presentation and T cell regulation. Different B cell subsets have been implicated in infections and multiple autoimmune dise...

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Detalles Bibliográficos
Autores principales: de Mol, Jill, Kuiper, Johan, Tsiantoulas, Dimitrios, Foks, Amanda C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524000/
https://www.ncbi.nlm.nih.gov/pubmed/34675924
http://dx.doi.org/10.3389/fimmu.2021.733566
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author de Mol, Jill
Kuiper, Johan
Tsiantoulas, Dimitrios
Foks, Amanda C.
author_facet de Mol, Jill
Kuiper, Johan
Tsiantoulas, Dimitrios
Foks, Amanda C.
author_sort de Mol, Jill
collection PubMed
description Aging is considered to be an important risk factor for several inflammatory diseases. B cells play a major role in chronic inflammatory diseases by antibody secretion, antigen presentation and T cell regulation. Different B cell subsets have been implicated in infections and multiple autoimmune diseases. Since aging decreases B cell numbers, affects B cell subsets and impairs antibody responses, the aged B cell is expected to have major impacts on the development and progression of these diseases. In this review, we summarize the role of B cells in health and disease settings, such as atherosclerotic disease. Furthermore, we provide an overview of age-related changes in B cell development and function with respect to their impact in chronic inflammatory diseases.
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spelling pubmed-85240002021-10-20 The Dynamics of B Cell Aging in Health and Disease de Mol, Jill Kuiper, Johan Tsiantoulas, Dimitrios Foks, Amanda C. Front Immunol Immunology Aging is considered to be an important risk factor for several inflammatory diseases. B cells play a major role in chronic inflammatory diseases by antibody secretion, antigen presentation and T cell regulation. Different B cell subsets have been implicated in infections and multiple autoimmune diseases. Since aging decreases B cell numbers, affects B cell subsets and impairs antibody responses, the aged B cell is expected to have major impacts on the development and progression of these diseases. In this review, we summarize the role of B cells in health and disease settings, such as atherosclerotic disease. Furthermore, we provide an overview of age-related changes in B cell development and function with respect to their impact in chronic inflammatory diseases. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8524000/ /pubmed/34675924 http://dx.doi.org/10.3389/fimmu.2021.733566 Text en Copyright © 2021 de Mol, Kuiper, Tsiantoulas and Foks https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
de Mol, Jill
Kuiper, Johan
Tsiantoulas, Dimitrios
Foks, Amanda C.
The Dynamics of B Cell Aging in Health and Disease
title The Dynamics of B Cell Aging in Health and Disease
title_full The Dynamics of B Cell Aging in Health and Disease
title_fullStr The Dynamics of B Cell Aging in Health and Disease
title_full_unstemmed The Dynamics of B Cell Aging in Health and Disease
title_short The Dynamics of B Cell Aging in Health and Disease
title_sort dynamics of b cell aging in health and disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524000/
https://www.ncbi.nlm.nih.gov/pubmed/34675924
http://dx.doi.org/10.3389/fimmu.2021.733566
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